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Calcitonin gene-related peptide (CGRP) relaxes vascular and intestinal smooth muscle. This study localized CGRP in the guinea pig gallbladder, examined the effects of CGRP on KCl- and ACh-induced contraction, and determined CGRPs site of action in the gallbladder. The gallbladder of male Hartley guinea pigs was used in in vitro tension studies, radioimmunoassay, or immunocytochemical studies. Radioimmunoassay showed that 8.0 +/- 0.5 pmol/g of immunoreactive CGRP was present. Immunocytochemistry demonstrated that immunoreactive-CGRP nerve fibers occurred around blood vessels, in gallbladder smooth muscle layers, and were associated with ganglia. No immunoreactive cell bodies were observed, even after colchicine treatment. The in vitro tension studies showed that CGRP inhibits either KCl- or acetylcholine-stimulated contraction. CGRP may in part act directly on the gallbladder smooth muscle to inhibit contraction.
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
December 1992,
Canadian journal of physiology and pharmacology,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
November 1996,
The American journal of physiology,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
March 1997,
Japanese journal of pharmacology,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
January 2004,
Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
August 1995,
British journal of pharmacology,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
March 1994,
Regulatory peptides,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
September 1997,
Regulatory peptides,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
September 1995,
Regulatory peptides,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
June 1992,
Annals of the New York Academy of Sciences,
L W Kline, and
T Kaneko, and
C G Benishin, and
P K Pang
August 1988,
Surgery,
