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Human pancreatic lipase (EC 3.1.1.3) is a 56-kDa protein secreted by the acinar pancreas and is essential for the hydrolysis and absorption of long-chain triglyceride fatty acids in the intestine. In vivo, the 12-kDa protein cofactor, colipase, is required to anchor lipase to the surface of lipid micelles, counteracting the destabilizing influence of bile salts. Southern blot analysis, using a pancreatic lipase cDNA to probe DNA from mouse-human somatic cell hybrids, indicated that the pancreatic lipase gene (PNLIP) resides on human chromosome 10. In situ hybridization to human metaphase chromosomes confirmed the cell hybrid results and further localized the gene to the 10q24-qter region with the strongest peak at q26.1.
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A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
August 1996,
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R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
January 1993,
Cytogenetics and cell genetics,
R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
January 1999,
Cytogenetics and cell genetics,
R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
March 1994,
Genomics,
R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
May 1991,
Genomics,
R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
July 1976,
Human genetics,
R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
December 2023,
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.],
R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
June 1995,
Mammalian genome : official journal of the International Mammalian Genome Society,
R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
February 1988,
Cancer genetics and cytogenetics,
R C Davis, and
A Diep, and
W Hunziker, and
I Klisak, and
T Mohandas, and
M C Schotz, and
R S Sparkes, and
A J Lusis
January 1997,
Cytogenetics and cell genetics,
