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Thirty children with refractory acute lymphocytic leukemia (ALL) were treated with mitoxantrone, 8 mg/m2/day, for 5 days. Three children received a second course of the drug 3 to 4 weeks later. All but two patients had received prior anthracycline therapy. There were 2 complete responses, 4 early deaths, and 24 patients with persistent leukemia. Of the 21 patients with circulating blasts at the start of mitoxantrone who did not achieve remission, 16 (76%) had complete clearance of their peripheral blood blasts. Although all patients developed profound neutropenia (less than 100 per mm-3), mucosal and hepatic toxicities were uncommon and mild. Mitoxantrone has moderate activity in childhood ALL and should be considered for further trials in less heavily pretreated patients.
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A H Ragab, and
K A Starling, and
D Rosen, and
R W Wilkenson, and
R W Wilkerson
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Cancer treatment reports,
M L Graham, and
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D Rosen, and
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R W Wilkerson
November 1983,
Cancer treatment reports,
M L Graham, and
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K A Starling, and
D Rosen, and
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M L Graham, and
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Cancer treatment reports,
M L Graham, and
J Estrada, and
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K A Starling, and
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Cancer treatment reports,
M L Graham, and
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Cancer research,
M L Graham, and
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Medical and pediatric oncology,
M L Graham, and
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August 1990,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
M L Graham, and
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K A Starling, and
D Rosen, and
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R W Wilkerson
January 1985,
Cancer treatment reports,
M L Graham, and
J Estrada, and
A H Ragab, and
K A Starling, and
D Rosen, and
R W Wilkenson, and
R W Wilkerson
April 1983,
Cancer treatment reports,
