Capillary gas chromatography (GC) is rapidly reaching a state of maturity. Recent advances in GC include new highly selective and stable open-tubular columns, capillary sampling techniques, and element-sensitive (plasma) detectors. An impressive growth of modern liquid chromatography continues with an emphasis on the separations of biopolymers, new silica-based and stable polymeric packings, microcolumn techniques, electroosmotically driven separations, and ultrasensitive detection. Supercritical fluid chromatography has gained considerable attention primarily because of its distinctive detection capabilities. Novel combinations of chromatographic techniques with each other, or with spectroscopic methods, continue to be explored.