BIOMAT Database Logo BIOMAT Database Logo

Actinomycin Binding to DNA: Inability of a DNA Containing Guanine To Bind Actinomycin D. 1969

R D Wells

Polydeoxy (adenylyl-thymidylyl-cytidylyl)* polydeoxy(guanylyl-adenylyl-thymidylyl), a double-stranded DNA polmer of high molecular weight containing 33 percent guanine plus cytosine, binds little or no actinomycin D, as measured by five different techniques. In contrast, the sequence isomer of this DNA, polydeoxy (thymidylyl-adenylyl-cytidylyl)-polydeoxy(guanylyl-thymidylyl-adenylyl), does bind the antibiotic. Thus, the presence of guanine in a DNA is not a sufficient requisite for the binding of actinomycin D.

UI MeSH Term Description Entries

Related Publications

R D Wells
[Binding of actinomycin D analogs to DNA].
January 1980, Biofizika,
R D Wells
Model nucleoproteins: binding of actinomycin D to complexes of DNA with lysine-containing polypeptides.
July 1978, Biopolymers,
R D Wells
Actinomycin D binding to unstructured, single-stranded DNA.
January 2001, Journal of molecular recognition : JMR,
R D Wells
Selective binding of actinomycin D and distamycin A to DNA.
November 1982, Nucleic acids research,
R D Wells
Unwinding of DNA by actinomycin D binding.
March 1971, Biochimica et biophysica acta,
R D Wells
Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA.
October 1991, Biochemistry,
R D Wells
The binding of actinomycin D and F to bacterial DNA.
October 1968, Biochimica et biophysica acta,
R D Wells
[Binding of actinomycin D analogues containing some substituents at position 7 of the antibiotic chromophore to DNA].
January 1979, Molekuliarnaia biologiia,
R D Wells
Competition between pentalysine and actinomycin D for binding to DNA.
February 1972, Biochemical and biophysical research communications,
R D Wells
7-Azido-actinomycin D: a photoaffinity probe of the sequence specificity of DNA binding by actinomycin D.
December 1989, Journal of biomolecular structure & dynamics,
Copied contents to your clipboard!