BIOMAT Database Logo BIOMAT Database Logo

Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis. 2007

D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai, India.

Perforin is one of the key effector molecules of cytotoxic T cells and natural killer cells. The influence of HLA-DRB1 alleles on peripheral blood perforin-positive CD4, CD8, CD16 and CD 56 cells was studied by flow cytometry. HLA-DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmonary tuberculosis (PTB: n = 102) by polymerase chain reaction-based sequence-specific oligonucleotide hybridization method. We observed a significantly decreased percentage of total perforin-positive cells (per(+)) (P = 0.0004); CD8(+)/Per(+) (P = 0.0005); CD16(+)/Per(+) (P = 0.05) and CD 56(+)/Per(+) cells (P = 0.001) in HLA-DR2-positive PTB patients compared to non-DR2 patients. Subtyping of HLA-DR2-positive subjects at the allelic level revealed that the percentage of CD8(+)/Per(+) cells did not differ among DRB1*1501 and DRB1*1502 patients while a trend towards a decreased percentage of CD16(+)/Per(+) and CD 56(+)/Per(+) cells was noticed in DRB1*1501 patients compared to DRB1*1502 patients. The present study suggests that HLA-DR2 may be associated with down-regulation of perforin-positive cytotoxic lymphocytes and natural killer cells in pulmonary tuberculosis.

UI MeSH Term Description Entries
D007694 Killer Cells, Natural Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type. NK Cells,Natural Killer Cells,Cell, NK,Cell, Natural Killer,Cells, NK,Cells, Natural Killer,Killer Cell, Natural,NK Cell,Natural Killer Cell
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013602 T-Lymphocytes, Cytotoxic Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2. Cell-Mediated Lympholytic Cells,Cytotoxic T Cells,Cytotoxic T Lymphocyte,Cytotoxic T-Lymphocytes,TC1 Cell,TC1 Cells,TC2 Cell,TC2 Cells,Cell Mediated Lympholytic Cells,Cell, Cell-Mediated Lympholytic,Cell, TC1,Cell, TC2,Cell-Mediated Lympholytic Cell,Cytotoxic T Cell,Cytotoxic T Lymphocytes,Cytotoxic T-Lymphocyte,Lymphocyte, Cytotoxic T,Lympholytic Cell, Cell-Mediated,Lympholytic Cells, Cell-Mediated,T Cell, Cytotoxic,T Lymphocyte, Cytotoxic,T Lymphocytes, Cytotoxic,T-Lymphocyte, Cytotoxic
D014397 Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung. Pulmonary Consumption,Pulmonary Phthisis,Pulmonary Tuberculoses,Pulmonary Tuberculosis,Tuberculoses, Pulmonary,Consumption, Pulmonary,Consumptions, Pulmonary,Phthises, Pulmonary,Phthisis, Pulmonary,Pulmonary Consumptions,Pulmonary Phthises
D015798 HLA-DR1 Antigen An HLA-DR antigen associated with HLA-DRB1 CHAINS that are encoded by DRB1*01 alleles. HLA-DR1,Antigen, HLA-DR1,HLA DR1 Antigen

Related Publications

D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
HLA-DR2 subtypes & immune responses in pulmonary tuberculosis.
April 2001, The Indian journal of medical research,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
Influence of HLA-DR2 phenotype on humoral immunity & lymphocyte response to Mycobacterium tuberculosis culture filtrate antigens in pulmonary tuberculosis.
May 1998, The Indian journal of medical research,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
Lymphocyte subsets in HLA-DR2-positive narcoleptic patients.
January 1985, Folia psychiatrica et neurologica japonica,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
HLA-DR2 phenotype and plasma lysozyme, beta-glucuronidase and acid phosphatase levels in pulmonary tuberculosis.
June 1997, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
HLA-DR2-DRB1 allele frequencies in DR2-positive black Americans with and without systemic lupus erythematosus.
October 1991, Tissue antigens,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
Delayed hypersensitivity and HLA in smear-positive pulmonary tuberculosis.
January 1995, International archives of allergy and immunology,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.
June 1995, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
A monoclonal antibody recognizing HLA-DR2 on malignant and activated cells.
January 1983, Immunogenetics,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
HLA-DR2 and narcolepsy.
January 1986, Sleep,
D N Rajeswari, and P Selvaraj, and S Raghavan, and M S Jawahar, and P R Narayanan
HLA-DR2 and narcolepsy.
August 1987, Archives of neurology,
Copied contents to your clipboard!