BIOMAT Database Logo BIOMAT Database Logo

No association between the -3081A/T polymorphism in the norepinephrine transporter gene promoter and personality traits in healthy subjects. 2007

Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, Japan. suzukiakihito@hotmail.com

There have been several data suggesting that norepinephrine neurotransmission is involved in the characterization of personality traits. Recently, the -3081A/T polymorphism in the promoter region of the norepinephrine transporter (NET) gene affecting promoter activity has been reported. In the present study, we studied the association between this NET polymorphism and personality traits in 553 Japanese healthy subjects. Personality traits were assessed by the Temperament and Character Inventory (TCI), and the NET genotypes were identified by a PCR-RFLP method. Multivariate two-factor analysis of covariance with genotype and gender as factors and with age as a covariate showed no association between the NET genotypes and the TCI dimension scores. The present study thus suggests that the -3081A/T polymorphism in the NET gene promoter is not involved in the characterization of personality traits in healthy subjects.

UI MeSH Term Description Entries
D007564 Japan A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo. Bonin Islands
D008297 Male Males
D010551 Personality Behavior-response patterns that characterize the individual. Personalities
D010556 Personality Tests Standardized objective tests designed to facilitate the evaluation of personality. Personality Test,Test, Personality,Tests, Personality
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D011401 Promoter Regions, Genetic DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. rRNA Promoter,Early Promoters, Genetic,Late Promoters, Genetic,Middle Promoters, Genetic,Promoter Regions,Promoter, Genetic,Promotor Regions,Promotor, Genetic,Pseudopromoter, Genetic,Early Promoter, Genetic,Genetic Late Promoter,Genetic Middle Promoters,Genetic Promoter,Genetic Promoter Region,Genetic Promoter Regions,Genetic Promoters,Genetic Promotor,Genetic Promotors,Genetic Pseudopromoter,Genetic Pseudopromoters,Late Promoter, Genetic,Middle Promoter, Genetic,Promoter Region,Promoter Region, Genetic,Promoter, Genetic Early,Promoter, rRNA,Promoters, Genetic,Promoters, Genetic Middle,Promoters, rRNA,Promotor Region,Promotors, Genetic,Pseudopromoters, Genetic,Region, Genetic Promoter,Region, Promoter,Region, Promotor,Regions, Genetic Promoter,Regions, Promoter,Regions, Promotor,rRNA Promoters
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D001923 Brain Chemistry Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states. Chemistry, Brain,Brain Chemistries,Chemistries, Brain
D004252 DNA Mutational Analysis Biochemical identification of mutational changes in a nucleotide sequence. Mutational Analysis, DNA,Analysis, DNA Mutational,Analyses, DNA Mutational,DNA Mutational Analyses,Mutational Analyses, DNA

Related Publications

Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
No association between CLOCK gene 3111C/T polymorphism and personality traits in healthy Japanese subjects.
October 2011, Psychiatry and clinical neurosciences,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
No association between the TPH A218C polymorphism and personality traits in Japanese healthy subjects.
March 2007, Progress in neuro-psychopharmacology & biological psychiatry,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects.
April 2010, Psychiatry and clinical neurosciences,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits.
January 2004, Neuropsychobiology,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
No association between a polymorphism in the serotonin receptor 2B (HTR2B) gene and personality traits in healthy Japanese subjects.
January 2013, Neuropsychobiology,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
Association between DARPP-32 gene polymorphism and personality traits in healthy Chinese-Han subjects.
May 2011, Journal of molecular neuroscience : MN,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
No association between serotonin transporter gene polymorphisms and personality traits.
August 1999, American journal of medical genetics,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
Gender differences in association between serotonin transporter gene polymorphism and personality traits.
December 2000, Psychiatric genetics,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females.
December 2005, Neuroscience letters,
Akihito Suzuki, and Yoshihiko Matsumoto, and Genki Ishii, and Shingo Oshino, and Kaoru Goto, and Koichi Otani
Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample.
April 2000, American journal of medical genetics,
Copied contents to your clipboard!