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There are conflicting reports concerning whether flumazenil (Ro15-1788) can antagonize the central effects of ethanol and ethanol withdrawal reactions. C57BL/6J mice were treated chronically with an ethanol liquid diet. Control mice were pair fed an isocaloric diet containing no ethanol. These mice were injected with either Ro15-1788 (25 mg/kg) or vehicle immediately before, 14 h or 24 h before ethanol withdrawal. Under these conditions, no attenuation of the severity of handling-induced withdrawal seizures or of withdrawal hypothermia was observed in the ethanol-dependent mice injected with Ro15-1788. Likewise, there was no abolition or attenuation of tolerance to the ataxic effects (sleep time and horizontal dowel tests) and hypothermic effects of ethanol by Ro15-1788 when the mice were tested on day 3 of ethanol withdrawal. It is concluded that Ro15-1788 (25 mg/kg) has no effect on ethanol tolerance and dependence.
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
November 1994,
Psychopharmacology,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
February 1992,
Alcoholism, clinical and experimental research,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
July 1994,
Psychopharmacology,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
May 1992,
Behavioral and neural biology,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
April 1994,
Research communications in chemical pathology and pharmacology,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
September 2005,
Anesthesia and analgesia,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
September 1996,
The European respiratory journal,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
January 1988,
Resuscitation,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
January 1987,
Progress in clinical and biological research,
A W Chan, and
F W Leong, and
D L Schanley, and
M C Langan, and
F Penetrante
June 1986,
Biological psychiatry,
