OBJECTIVE To describe and illustrate examples of early-stage larynx and hypopharynx cancer that can be successfully treated with radiotherapy alone. METHODS Review of the NCCN and ASCO practice guidelines. Representative examples are included. RESULTS Early-stage larynx and hypopharynx cancer is defined by tumor extent based on physical and imaging examination. CONCLUSIONS Radiotherapy alone is appropriate treatment for properly selected early-stage squamous cell carcinoma of the larynx and hypopharynx. The NCCN and ASCO practice guidelines can be an aid to the clinician in identifying favorable cancers that can be successfully treated with radiotherapy alone with preservation of organ function.