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The effects of growth hormone and ACTH, alone or in combination, on fetal rat adrenal steroidogenesis in vitro were examined on the last day of intrauterine development. ACTH increased, while growth hormone did not affect fetal adrenal weight. ACTH increased fetal rat adrenal steroidogenesis, hydroxylation of 4-14C-progesterone to corticosterone, 18-hydroxy-11-deoxycorticosterone, 11-hydroxycorticosterone and aldosterone. Growth hormone alone had no effect on fetal adrenal steroidogenesis. ACTH and growth hormone administered together increased the conversion of progesterone to the above mentioned steroids to a greater extent than ACTH alone. The results indicate that growth hormone may participate in the fetal rat adrenal steroidogenesis potentiating the effects of fetal pituitary ACTH.
R Klepac, and
K Milković
January 1991,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
R Klepac, and
K Milković
April 1981,
Endokrinologie,
R Klepac, and
K Milković
January 1981,
Biology of the neonate,
R Klepac, and
K Milković
April 1982,
Endocrinologia japonica,
R Klepac, and
K Milković
October 1977,
Annals of the New York Academy of Sciences,
R Klepac, and
K Milković
April 1981,
Nature,
R Klepac, and
K Milković
October 1976,
Research communications in chemical pathology and pharmacology,
R Klepac, and
K Milković
January 1982,
Experimental aging research,
R Klepac, and
K Milković
March 1970,
Endocrinology,
