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Electron microscopic examination on three lines of transplantable reticulum cell sarcomas, induced spontaneously in the mesenteric lymph nodes of inbred strain ACI rats, proved the presence of intracisternal A particles in all the three tumor lines. The doughnut-shaped particles measured 50 to 70 nm and were seen to bud from the membranes of rough-surfaced endoplasmic reticulum. Frequency of appearance of these particles varied with the tumor line.
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