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In a prospective study, 23 children with infantile spasms received intravenous gammaglobulins in high doses. 19 patients present a West syndrome. 4 older patients were included in the study because infantile spasms had preceded their Lennox-Gastaut syndrome. None of the patients had recently undergone corticosteroid therapy. No effect was observed in 15 patients, while transitory clinical and/or electroencephalographic improvement was noted in 3. Complete normalization was obtained in the remaining 5 patients, of whom 4 had severe brain lesions. No correlation existed between the therapeutic results and immunological abnormalities, a deficiency in IgG subclasses in particular. On the whole, the therapeutic results were disappointing. But the existence of some cases in which spectacular electroencephalographic and/or clinical improvement was obtained leads us to suggest that IV gamma-globulins be used as auxiliary treatment in infantile spasms.
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M Baldy-Moulinier
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M Andary, and
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B Echenne, and
O Dulac, and
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M Andary, and
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M Baldy-Moulinier
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B Echenne, and
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B Echenne, and
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M Baldy-Moulinier
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B Echenne, and
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C Chiron, and
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J Clot, and
M Baldy-Moulinier
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Pediatrie,
