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Cytotoxic effect of prostaglandins E2 and F2alpha on cells grown in vitro and the influence of these compounds on multiplication of myxovirus parainfluenza 3 were investigated. The prostaglandins were added to culture medium (0-01-10 mug/ml) 24 hr before virus infection, or for 2 and 48 hr after inoculation with viruses. WISH cells and monkey kidney cell cultures were used. No direct cytotoxic effect of prostaglandins at concentrations 0-01-1 mug/ml was found (viability, supravital staining, phase-contrast system, Nitro-BT reduction and succinic dehydrogenase tests), whereas the concentration of 10 mug/ml within 48 hr led to reduction and succinic dehydrogenase tests), whereas the concentration of 10 mug/ml within 48 hr led to partial injury of the cell population with symptoms of damage to mitochondria. Prostaglandins E2 and F2alpha inhibited multiplication of parainfluenza 3 virus at concentrations 0-1-10 mug/ml. The inhibitory effect was most pronounced if prostaglandins were added to medium for the whole period of virus multiplication i.e. for 48 hr but little or no effect was found if they were added prior to inoculation or for 2 hr after it. Inhibitory effect of prostaglandins on replication phase of viruses is suggested.
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
March 1971,
Acta virologica,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
January 1977,
Acta virologica,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
January 1964,
Acta pathologica et microbiologica Scandinavica,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
April 2000,
Research in veterinary science,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
April 1967,
Virology,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
July 1966,
Nature,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
September 1971,
Acta virologica,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
July 1968,
Acta virologica,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
January 1972,
Studii si cercetari de virusologie,
M Luczak, and
W Gumulka, and
S Szmigielski, and
M Korbecki, and
W Lasota
January 1968,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
