BIOMAT Database Logo BIOMAT Database Logo

In vivo effects of human recombinant tumor necrosis factor alone and in combination with other biological response modifiers on human digestive organ cancer xenografts transplanted in nude mice. 1991

Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
First Department of Surgery, Kyoto University Faculty of Medicine, Japan.

The present study was designed to evaluate the effect of rTNF alone or in combination with other BRMs on human digestive organ cancers. Six kinds of human digestive organ cancer xenografts (esophageal, stomach, colonic, pancreatic, bile duct, and liver cancers: EC-YO, GC-YN, CC-KK, PC-HN, BDC-SN and Li-7, respectively) were transplanted in nude mice, and rTNF was administered at 10(3), 5 x 10(3), or 10(4)U/head directly into the tumor 3 times a week for 2 weeks. EC-YO was the most sensitive to rTNF, and intratumoral administration of rTNF at 10(3) U/head caused tumor regression. PC-HN, CC-KK and GC-YN were relatively sensitive to rTNF, and their growth was significantly inhibited by rTNF at 5 x 10(3) U/head, however, the tumors regrew after treatment. Li-7 and BDC-SN were resistant to rTNF. The effects of rTNF in combination with recombinant interferon-gamma (rIFN-gamma), recombinant interleukin-2 (rIL-2), or streptococcal preparation OK-432 were assessed in mice transplanted with GC-YN. All combinations of rTNF at 5 x 10(3) U/head and other BRMs were more effective than rTNF alone, and GC-YN tumors were completely regressed after treatment with a combination of rTNF and rIFN-gamma or rTNF and OK-432. However in all cases, the combination of rTNF at 10(3) U/head and any other BRM did not improve the effect. Furthermore, the adverse effects of the combinations were more serious than those of rTNF alone. TNF may still be a useful cytokine, because it can induce the regression of tumors. However, for its clinical application, a method should be developed to reduce its side effects.

UI MeSH Term Description Entries
D007155 Immunologic Factors Biologically active substances whose activities affect or play a role in the functioning of the immune system. Biological Response Modifier,Biomodulator,Immune Factor,Immunological Factor,Immunomodulator,Immunomodulators,Biological Response Modifiers,Biomodulators,Factors, Immunologic,Immune Factors,Immunological Factors,Modifiers, Biological Response,Response Modifiers, Biological,Factor, Immune,Factor, Immunological,Factors, Immune,Factors, Immunological,Modifier, Biological Response,Response Modifier, Biological
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D007376 Interleukin-2 A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes. IL-2,Lymphocyte Mitogenic Factor,T-Cell Growth Factor,TCGF,IL2,Interleukin II,Interleukine 2,RU 49637,RU-49637,Ro-23-6019,Ro-236019,T-Cell Stimulating Factor,Thymocyte Stimulating Factor,Interleukin 2,Mitogenic Factor, Lymphocyte,RU49637,Ro 23 6019,Ro 236019,Ro236019,T Cell Growth Factor,T Cell Stimulating Factor
D008297 Male Males
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008819 Mice, Nude Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses. Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D009368 Neoplasm Transplantation Experimental transplantation of neoplasms in laboratory animals for research purposes. Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D010844 Picibanil A lyophilized preparation of a low-virulence strain (SU) of Streptococcus pyogenes (S. hemolyticus), inactivated by heating with penicillin G. It has been proposed as a noncytotoxic antineoplastic agent because of its immune system-stimulating activity. NSC-B116209,OK-432,Picibanyl,Streptococcal OK-432,Streptococcal Preparation OK-432,NSC B116209,NSCB116209,OK 432,OK432,Streptococcal OK 432,Streptococcal OK432,Streptococcal Preparation OK 432,Streptococcal Preparation OK432
D011994 Recombinant Proteins Proteins prepared by recombinant DNA technology. Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D004067 Digestive System Neoplasms Tumors or cancer of the DIGESTIVE SYSTEM. Cancer of Digestive System,Digestive System Cancer,Cancer of the Digestive System,Neoplasms, Digestive System,Cancer, Digestive System,Cancers, Digestive System,Digestive System Cancers,Digestive System Neoplasm,Neoplasm, Digestive System

Related Publications

Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Antitumor effects of recombinant human tumor necrosis factor against human tumor xenografts transplanted into nude mice.
January 1987, The Japanese journal of surgery,
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons.
August 1986, Cancer research,
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Effect of biological response modifiers on growth and cell proliferation of human tumor xenografts in nude mice.
February 1995, Cellular and molecular biology (Noisy-le-Grand, France),
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Effects of natural interferon alpha, natural tumor necrosis factor alpha and their combination on human mesothelioma xenografts in nude mice.
January 1993, Cancer immunology, immunotherapy : CII,
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Effects of tumour necrosis factor on human tumour xenografts in nude mice.
January 1987, Ciba Foundation symposium,
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
[Anti-tumor effect of human recombinant tumor necrosis factor on the human renal cell carcinoma serially transplanted into nude mice].
October 1988, Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Recombinant human tumor necrosis factor alone and with chemotherapeutic agents. Effect on nude mouse-supported human bladder cancer heterografts.
January 1989, Archives of surgery (Chicago, Ill. : 1960),
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Differential antiproliferative activities of alpha- and gamma-interferon and tumor necrosis factor alone or in combinations against two prostate cancer xenografts transplanted in nude mice.
January 1991, The Prostate,
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with fluoropyrimidine anticancer agent, S-1, on tumor growth of human oral squamous cell carcinoma xenografts in nude mice.
January 2007, Anticancer research,
Y Nio, and T Shiraishi, and M Tsubono, and H Morimoto, and C C Tseng, and K Kawabata, and Y Masai, and T Tun, and M Fukumoto, and T Tobe
Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice.
April 1990, Cancer research,
Copied contents to your clipboard!