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Amino-caprolactam derivatives as gamma-secretase inhibitors. 2007
Michael F Parker, and
Joanne J Bronson, and
Donna M Barten, and
Jason A Corsa, and
Wengsheng Du, and
Kevin M Felsenstein, and
Valerie L Guss, and
Darcy Izzarelli, and
Alice Loo, and
Kate E McElhone, and
Larry R Marcin, and
Ramesh Padmanabha, and
Roger Pak, and
Craig T Polson, and
Jeremy H Toyn, and
Sam Varma, and
Jian Wang, and
Victoria Wong, and
Ming Zheng, and
Susan B Roberts
Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. parkerm@BMS.com
A series of amino-caprolactam sulfonamides were developed from a screening hit. Compounds with good in vitro and in vivo gamma-secretase activity are reported.
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