Biomaterial Database

[Distribution of vanadium in tissues of nonpregnant and pregnant Wistar rats]. 1991

S Li, and T Zhang, and Z Yang, and X Gou

Department of Environmental Health.

This paper reports tissue distribution of vanadium in nonpregnant and pregnant Wistar rats. The experimental results showed that vanadium concentrations in nonpregnant rats were respectively from high to low: I. no treatment: ovary greater than uterus greater than kidney greater than lung greater than heart muscle greater than spleen greater than brain greater than liver greater than blood; II. 4h after single i.p. injection of V2O5 (5 mg/kg): kidney greater than ovary greater than liver greater than bone greater than uterus greater than lung greater than heart muscle greater than spleen greater than brain greater than blood. The results suggest that female genital organs are important organs in distribution of vanadium. The kidney is a main excretory organ. After 24h of treatment, a larger amount of vanadium in body has been excreted. Vanadium can pass through blood-brain barrier. Distribution of vanadium on gestation days 12 after 4h single i.p. injection of V2O5 (5 mg/kg) is: kidney greater than ovary greater than uterus greater than placenta greater than liver greater than fetus greater than bone greater than heart muscle greater than lung greater than brain greater than spleen greater than blood; on gestation days 16-18 after 4h single i.p. injection of V2O5 (5 mg/kg) is: kidney ovary greater than placenta greater than lung greater than bone greater than uterus greater than heart muscle greater than spleen greater than fetus greater than liver greater than brain greater than blood; after 24h (on gestation days 16-18) is: kidney greater than ovary greater than placenta greater than spleen greater than bone greater than lung greater than liver greater than fetus heart muscle greater than brain blood.(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D007274	Injections, Intraperitoneal	Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.	Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011270	Pregnancy, Animal	The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.	Animal Pregnancies,Animal Pregnancy,Pregnancies, Animal
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D005260	Female		Females
D005836	Genitalia, Female	The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.	Accessory Sex Organs, Female,Sex Organs, Accessory, Female,Genital Organs, Female,Genitals, Female,Reproductive System, Female,Female Genital,Female Genital Organ,Female Genital Organs,Female Genitalia,Female Genitals,Female Reproductive System,Female Reproductive Systems,Genital Organ, Female,Genital, Female,Reproductive Systems, Female
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D014639	Vanadium	A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.	Vanadium-51,Vanadium 51
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus