BIOMAT Database Logo BIOMAT Database Logo

Pretargeted radioimmunotherapy for B-cell lymphomas. 2007

Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Clinical Research Division, Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington, Seattle, Washington 98109, USA. dgreen@fhcrc.org

Relapsed or treatment refractory B-cell lymphomas are currently incurable with conventional chemotherapy and radiation treatments. High-dose chemoradiotherapy and stem cell transplantation can cure some patients with relapsed or refractory lymphoma, but the majority of such patients die of progressive disease. We have investigated the potential utility of pretargeted radioimmunotherapy using monoclonal antibody-streptavidin, immunoconjugates, and fusion proteins in combination with N-acetylgalactosamine dendrimeric clearing agent and radiometal-labeled 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid biotin for treatment of lymphomas using mouse and primate models. We have targeted a variety of cell surface antigens, including CD20, CD22, CD45, and HLA-DR, using conventional and pretargeted radioimmunotherapy. These studies showed the marked superiority of pretargeted radioimmunotherapy for each of the antigenic targets in terms of superior biodistributions, more complete tumor regressions, and longer survival. We are optimistic that this novel approach will provide a meaningful prolongation of survival for patients with relapsed or refractory lymphomas.

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000911 Antibodies, Monoclonal Antibodies produced by a single clone of cells. Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D016393 Lymphoma, B-Cell A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. B-Cell Lymphoma,B Cell Lymphoma,B-Cell Lymphomas,Lymphoma, B Cell,Lymphomas, B-Cell
D016499 Radioimmunotherapy Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY). Immunoradiotherapy,Immunoradiotherapies,Radioimmunotherapies

Related Publications

Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Comparison of anti-CD20 and anti-CD45 antibodies for conventional and pretargeted radioimmunotherapy of B-cell lymphomas.
March 2003, Blood,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Radioimmunotherapy for B-cell non-hodgkin lymphomas.
July 2012, Cancer control : journal of the Moffitt Cancer Center,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Pretargeted radioimmunotherapy.
January 2005, Ernst Schering Research Foundation workshop,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Pretargeted radioimmunotherapy.
January 2006, International journal of radiation oncology, biology, physics,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Tools for pretargeted radioimmunotherapy.
April 2001, Cancer biotherapy & radiopharmaceuticals,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
High-dose radioimmunotherapy of B cell lymphomas.
January 1990, Frontiers of radiation therapy and oncology,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies.
February 2018, Blood,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Doubly radiolabeled liposomes for pretargeted radioimmunotherapy.
November 2007, International journal of pharmaceutics,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Evidence mounts for the efficacy of radioimmunotherapy for B-cell lymphomas.
November 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Damian J Green, and John M Pagel, and Anastasia Pantelias, and Nathan Hedin, and Yukang Lin, and D Scott Wilbur, and Ajay Gopal, and Donald K Hamlin, and Oliver W Press
Radioimmunotherapy for treatment of B-cell lymphomas and other hematologic malignancies.
November 2007, Current opinion in hematology,
Copied contents to your clipboard!