[Usefulness of hepatic arterial infusion chemotherapy using lecithin-added lipiodol emulsion in hepatocellular carcinoma]. 2007

Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University.

After implanting a reservoir in the hepatic artery, we performed intra-arterial chemotherapy with a smaller particle size lipiodol emulsion and examined its therapeutic effect. Subjects were 21 patients with advanced/recurrent hepatocellular carcinoma (HCC). Arterial infusion was performed once every 2 weeks on an outpatient basis using 2 mL lipiodol emulsion with lecithin added as a surface active agent and 10 mg doxorubicin hydrochloride. As of 6 months after the start of treatment, the response rate was 38.1%. Median survival was 17.0 months. Serious adverse events were not noted in any of the subjects;during the course of treatment, catheter occlusion was observed in 2 patients. This therapy allows fewer visits and provides a relatively substantial therapeutic effect while maintaining QOL, so it may serve as an effective treatment for highly advanced/multiple HCC not suited to other treatments.

UI MeSH Term Description Entries
D007261 Infusions, Intra-Arterial Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease. Infusions, Regional Arterial,Infusions, Intra Arterial,Infusions, Intraarterial,Arterial Infusion, Intra,Arterial Infusion, Regional,Arterial Infusions, Intra,Arterial Infusions, Regional,Infusion, Intra Arterial,Infusion, Intra-Arterial,Infusion, Intraarterial,Infusion, Regional Arterial,Intra Arterial Infusion,Intra Arterial Infusions,Intra-Arterial Infusion,Intra-Arterial Infusions,Intraarterial Infusion,Intraarterial Infusions,Regional Arterial Infusion,Regional Arterial Infusions
D007459 Iodized Oil A preparation of oil that contains covalently bound IODINE. It is commonly used as a RADIOCONTRAST AGENT and as a suspension medium for CHEMOTHERAPEUTIC AGENTS. Oil, Iodized,Iodized Oils,Iodolipol,Oils, Iodized
D008113 Liver Neoplasms Tumors or cancer of the LIVER. Cancer of Liver,Hepatic Cancer,Liver Cancer,Cancer of the Liver,Cancer, Hepatocellular,Hepatic Neoplasms,Hepatocellular Cancer,Neoplasms, Hepatic,Neoplasms, Liver,Cancer, Hepatic,Cancer, Liver,Cancers, Hepatic,Cancers, Hepatocellular,Cancers, Liver,Hepatic Cancers,Hepatic Neoplasm,Hepatocellular Cancers,Liver Cancers,Liver Neoplasm,Neoplasm, Hepatic,Neoplasm, Liver
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010316 Particle Size Relating to the size of solids. Particle Sizes,Size, Particle,Sizes, Particle
D010713 Phosphatidylcholines Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety. Choline Phosphoglycerides,Choline Glycerophospholipids,Phosphatidyl Choline,Phosphatidyl Cholines,Phosphatidylcholine,Choline, Phosphatidyl,Cholines, Phosphatidyl,Glycerophospholipids, Choline,Phosphoglycerides, Choline
D004621 Embolization, Therapeutic A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage. Embolotherapy,Therapeutic Embolization,Embolizations, Therapeutic,Embolotherapies,Therapeutic Embolizations
D004655 Emulsions Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES. Emulsion
D005260 Female Females

Related Publications

Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
November 2012, Anticancer research,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
August 1989, Gan to kagaku ryoho. Cancer & chemotherapy,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
February 1998, Gan to kagaku ryoho. Cancer & chemotherapy,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
August 1990, Rinsho hoshasen. Clinical radiography,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
December 2004, Gan to kagaku ryoho. Cancer & chemotherapy,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
August 2012, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
November 1997, Gan to kagaku ryoho. Cancer & chemotherapy,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
January 2016, Gan to kagaku ryoho. Cancer & chemotherapy,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
November 2003, AJR. American journal of roentgenology,
Shinjiro Kobayashi, and Satoshi Koizumi, and Satoshi Katagiri, and Shunichi Ariizumi, and Yutaka Takahashi, and Takehito Otsubo, and Ken Takasaki, and Masakazu Yamamoto
June 2010, Asia-Pacific journal of clinical oncology,
Copied contents to your clipboard!