Biomaterial Database

[Scientific contribution of Sutherland's "the second messenger hypothesis"]. 2007

Xiao-qiang Guo

Department of Biochemistry, Bethune Military Medical College, Shijiazhuang 050081, China.

Signal transduction is one of the most important fields of life science. The discovery of cAMP and description of the second messenger hypothesis by Sutherland is the landmark of signal transduction. In this paper, the background and course of cAMP discovery were demonstrated and at the same time the content and significance of the second messenger hypothesis were illustrated, so scientific contribution of the second messenger hypothesis can be approximately understood.

UI	MeSH Term	Description	Entries
D015290	Second Messenger Systems	Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.	Intracellular Second Messengers,Second Messengers,Intracellular Second Messenger,Messenger, Second,Messengers, Intracellular Second,Messengers, Second,Second Messenger,Second Messenger System,Second Messenger, Intracellular,Second Messengers, Intracellular,System, Second Messenger,Systems, Second Messenger