[Effect of santalol on the sleep-wake cycle in sleep-disturbed rats]. 2007

Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.

Sandalwood oil is widely used in aromatherapy for alleviating various symptoms. Santalol, a major component of sandalwood oil, has been reported to have central nervous system depressant effects such as sedation. In the present study, we investigated the effect of santalol on the sleep-wake cycle in sleep-disturbed rats. When inhaled at a concentration of 5 X 10(-2) ppm, santalol caused a significant decrease in total waking time and an increase in total non-rapid eye movement (NREM) sleep time. In order to clarify the mechanism of action, olfactory hypofunction was caused in rats by intranasal application of 5% zinc sulfate solution, and thereafter the effects of inhalation of fragrances were evaluated. In this study, it was found that the impairment of the olfactory system showed no significant effect on the changes in sleep parameters induced by santalol. This result suggests that santalol may act via the circulatory system rather than the olfactory system. That is, santalol is thought to be absorbed into the blood through the respiratory mucosa, and then exert its action. From these results, it is concluded that santalol may be useful in patients having difficulty maintaining sleep without being affected by individual differences in perfume-related preference.

UI MeSH Term Description Entries
D008297 Male Males
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000081223 Polycyclic Sesquiterpenes Sesquiterpenes that contain two or more ring structures Caryophyllane,Caryophyllane Derivative,Caryophyllane Derivatives,Caryophyllanes,Eremophilane,Eremophilane Derivative,Eremophilane Derivatives,Eremophilanes,Polycyclic Sesquiterpene,Valerane,Valerane Derivative,Valerane Derivatives,Valeranes,Derivative, Caryophyllane,Derivative, Eremophilane,Derivative, Valerane,Derivatives, Caryophyllane,Derivatives, Eremophilane,Derivatives, Valerane,Sesquiterpene, Polycyclic,Sesquiterpenes, Polycyclic
D000280 Administration, Inhalation The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract. Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012717 Sesquiterpenes Fifteen-carbon compounds formed from three isoprenoid units with general formula C15H24. Farnesanes,Farnesene,Farnesenes,Sesquiterpene,Sesquiterpene Derivatives,Sesquiterpenoid,Sesquiterpenoids,Derivatives, Sesquiterpene
D012893 Sleep Wake Disorders Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle. Sleep Disorders,Long Sleeper Syndrome,Short Sleep Phenotype,Short Sleeper Syndrome,Sleep-Related Neurogenic Tachypnea,Subwakefullness Syndrome,Disorder, Sleep,Disorder, Sleep Wake,Disorders, Sleep,Disorders, Sleep Wake,Long Sleeper Syndromes,Neurogenic Tachypnea, Sleep-Related,Neurogenic Tachypneas, Sleep-Related,Phenotype, Short Sleep,Phenotypes, Short Sleep,Short Sleep Phenotypes,Short Sleeper Syndromes,Sleep Disorder,Sleep Phenotypes, Short,Sleep Related Neurogenic Tachypnea,Sleep Wake Disorder,Sleep-Related Neurogenic Tachypneas,Sleeper Syndrome, Long,Sleeper Syndrome, Short,Sleeper Syndromes, Long,Sleeper Syndromes, Short,Subwakefullness Syndromes,Syndrome, Long Sleeper,Syndrome, Short Sleeper,Syndrome, Subwakefullness,Syndromes, Long Sleeper,Syndromes, Short Sleeper,Syndromes, Subwakefullness,Tachypnea, Sleep-Related Neurogenic,Tachypneas, Sleep-Related Neurogenic,Wake Disorder, Sleep,Wake Disorders, Sleep
D012894 Sleep Stages Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; they formerly included Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep. In 2007, sleep stages were redefined by The American Academy of Sleep Medicine (AASM) as: N1-N2 (sleep onset - light sleep), N3 (SLOW-WAVE SLEEP), and REM SLEEP. N1-Sleep,N2-Sleep,NREM Stage 1,NREM Stage 2,N1 Sleep,N2 Sleep,Sleep Stage,Stage, Sleep,Stages, Sleep
D012903 Smell The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS. Olfaction,Sense of Smell,Smell Sense
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats

Related Publications

Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
November 2008, Indian journal of pharmaceutical sciences,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
June 2005, Acta medica Okayama,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
February 2007, Journal of pharmacological sciences,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
February 2009, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
February 2007, Biological & pharmaceutical bulletin,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
May 2011, The Journal of family practice,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
April 2004, Psychopharmacology,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
June 2015, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
September 2006, Toxicology,
Asae Ohmori, and Kazuaki Shinomiya, and Yoshiaki Utsu, and Shin Tokunaga, and Yasuyuki Hasegawa, and Chiaki Kamei
June 1993, Neuroscience letters,
Copied contents to your clipboard!