BIOMAT Database Logo BIOMAT Database Logo

[Drug-induced hypersensitivity due to phenytoin]. 2007

Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
Department of Pediatrics, Nagoya First Red Cross Hospital, Nagoya, Aichi.

This study aimed to clarify factors associated with intravenous administered phenytoin-induced hypersensitivity reaction. The incidence of hypersensitivity was significantly more frequent in boys than in girls (P < 0.05). Patients with hypersensitivity were relatively younger than those without hypersensitivity, although the difference was not statistically significant. There was no relation between the initial dose or maximum blood level of phenytoin and the occurrence of hypersensitivity. The initial serum level of phenytoin was significantly lower in patients with hypersensitivity than in those without hypersensitivity (P < 0.05), whereas the total dose of phenytoin was relatively larger in patients with hypersensitivity than those without. Reactivation of human herpes virus-6 was not recognized in all 3 patients in whom virological examination was performed using real-time polymerase chain reaction.

UI MeSH Term Description Entries
D008297 Male Males
D010672 Phenytoin An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. Diphenylhydantoin,Fenitoin,Phenhydan,5,5-Diphenylhydantoin,5,5-diphenylimidazolidine-2,4-dione,Antisacer,Difenin,Dihydan,Dilantin,Epamin,Epanutin,Hydantol,Phenytoin Sodium,Sodium Diphenylhydantoinate,Diphenylhydantoinate, Sodium
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004342 Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally. Allergy, Drug,Hypersensitivity, Drug,Drug Allergy,Allergies, Drug,Drug Allergies,Drug Hypersensitivities,Hypersensitivities, Drug
D004827 Epilepsy A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313) Aura,Awakening Epilepsy,Seizure Disorder,Epilepsy, Cryptogenic,Auras,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Seizure Disorders
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000927 Anticonvulsants Drugs used to prevent SEIZURES or reduce their severity. Anticonvulsant,Anticonvulsant Drug,Anticonvulsive Agent,Anticonvulsive Drug,Antiepileptic,Antiepileptic Agent,Antiepileptic Agents,Antiepileptic Drug,Anticonvulsant Drugs,Anticonvulsive Agents,Anticonvulsive Drugs,Antiepileptic Drugs,Antiepileptics,Agent, Anticonvulsive,Agent, Antiepileptic,Agents, Anticonvulsive,Agents, Antiepileptic,Drug, Anticonvulsant,Drug, Anticonvulsive,Drug, Antiepileptic,Drugs, Anticonvulsant,Drugs, Anticonvulsive,Drugs, Antiepileptic

Related Publications

Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
[Hypersensitivity myocarditis probably due to phenytoin].
January 1988, Nihon geka hokan. Archiv fur japanische Chirurgie,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
Interstitial nephritis due to phenytoin hypersensitivity.
September 1977, The Journal of pediatrics,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
[Drug-induced hypersensitivity syndrome due to gabapentin].
March 2008, Annales de dermatologie et de venereologie,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
Drug hypersensitivity to previously tolerated phenytoin by carbamazepine-induced DRESS syndrome.
August 2006, Journal of Korean medical science,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
A case of hypersensitivity syndrome due to phenytoin.
October 2002, The Journal of dermatology,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
A case of hypersensitivity syndrome due to phenytoin.
January 2008, Journal of investigational allergology & clinical immunology,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
Phenytoin-induced hypersensitivity reactions.
September 1987, Clinical pharmacy,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
Acute kidney injury due to drug-induced hypersensitivity.
April 2015, Prescrire international,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
Drug-induced hypersensitivity syndrome due to carbapenem antibiotics.
April 2010, The Journal of dermatology,
Seiko Itomi, and Akihisa Okumura, and Taketo Ikuta, and Yoshiko Suzuki, and Toru Kato, and Tamiko Negoro, and Kazuyoshi Watanabe
[A case of drug-induced interstitial pneumonia due to phenytoin].
August 2009, Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society,
Copied contents to your clipboard!