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Detection of anti-ovarian antibodies by indirect immunofluorescence in patients with premature ovarian failure. 1991
Department of Obstetrics and Gynaecology, Kolling Institute of Medical Research, St Leonards, NSW, Australia.
The sera of 30 patients with premature ovarian failure (POF) and a control group of 19 menopausal women were screened for anti-ovarian and other tissue antibodies. Anti-ovarian antibodies were detected by indirect immunofluorescence using monkey ovary substrates from two different commercial sources. Serum anti-ovarian antibodies were detected in only one of the patients with POF. This test does not appear to be reliable for the detection of serum anti-ovarian antibodies, and the clinical usefulness of screening patients with POF for anti-ovarian antibodies is questionable.
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