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Draft genome of the filarial nematode parasite Brugia malayi. 2007
Elodie Ghedin, and
Shiliang Wang, and
David Spiro, and
Elisabet Caler, and
Qi Zhao, and
Jonathan Crabtree, and
Jonathan E Allen, and
Arthur L Delcher, and
David B Guiliano, and
Diego Miranda-Saavedra, and
Samuel V Angiuoli, and
Todd Creasy, and
Paolo Amedeo, and
Brian Haas, and
Najib M El-Sayed, and
Jennifer R Wortman, and
Tamara Feldblyum, and
Luke Tallon, and
Michael Schatz, and
Martin Shumway, and
Hean Koo, and
Steven L Salzberg, and
Seth Schobel, and
Mihaela Pertea, and
Mihai Pop, and
Owen White, and
Geoffrey J Barton, and
Clotilde K S Carlow, and
Michael J Crawford, and
Jennifer Daub, and
Matthew W Dimmic, and
Chris F Estes, and
Jeremy M Foster, and
Mehul Ganatra, and
William F Gregory, and
Nicholas M Johnson, and
Jinming Jin, and
Richard Komuniecki, and
Ian Korf, and
Sanjay Kumar, and
Sandra Laney, and
Ben-Wen Li, and
Wen Li, and
Tim H Lindblom, and
Sara Lustigman, and
Dong Ma, and
Claude V Maina, and
David M A Martin, and
James P McCarter, and
Larry McReynolds, and
Makedonka Mitreva, and
Thomas B Nutman, and
John Parkinson, and
José M Peregrín-Alvarez, and
Catherine Poole, and
Qinghu Ren, and
Lori Saunders, and
Ann E Sluder, and
Katherine Smith, and
Mario Stanke, and
Thomas R Unnasch, and
Jenna Ware, and
Aguan D Wei, and
Gary Weil, and
Deryck J Williams, and
Yinhua Zhang, and
Steven A Williams, and
Claire Fraser-Liggett, and
Barton Slatko, and
Mark L Blaxter, and
Alan L Scott
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. GhedinE@dom.pitt.edu
Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during approximately 350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.
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Najib M El-Sayed, and
Jennifer R Wortman, and
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Mihaela Pertea, and
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Jeremy M Foster, and
Mehul Ganatra, and
William F Gregory, and
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Richard Komuniecki, and
Ian Korf, and
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Wen Li, and
Tim H Lindblom, and
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David M A Martin, and
James P McCarter, and
Larry McReynolds, and
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Larry McReynolds, and
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John Parkinson, and
José M Peregrín-Alvarez, and
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Lori Saunders, and
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Katherine Smith, and
Mario Stanke, and
Thomas R Unnasch, and
Jenna Ware, and
Aguan D Wei, and
Gary Weil, and
Deryck J Williams, and
Yinhua Zhang, and
Steven A Williams, and
Claire Fraser-Liggett, and
Barton Slatko, and
Mark L Blaxter, and
Alan L Scott
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Elisabet Caler, and
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David B Guiliano, and
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Samuel V Angiuoli, and
Todd Creasy, and
Paolo Amedeo, and
Brian Haas, and
Najib M El-Sayed, and
Jennifer R Wortman, and
Tamara Feldblyum, and
Luke Tallon, and
Michael Schatz, and
Martin Shumway, and
Hean Koo, and
Steven L Salzberg, and
Seth Schobel, and
Mihaela Pertea, and
Mihai Pop, and
Owen White, and
Geoffrey J Barton, and
Clotilde K S Carlow, and
Michael J Crawford, and
Jennifer Daub, and
Matthew W Dimmic, and
Chris F Estes, and
Jeremy M Foster, and
Mehul Ganatra, and
William F Gregory, and
Nicholas M Johnson, and
Jinming Jin, and
Richard Komuniecki, and
Ian Korf, and
Sanjay Kumar, and
Sandra Laney, and
Ben-Wen Li, and
Wen Li, and
Tim H Lindblom, and
Sara Lustigman, and
Dong Ma, and
Claude V Maina, and
David M A Martin, and
James P McCarter, and
Larry McReynolds, and
Makedonka Mitreva, and
Thomas B Nutman, and
John Parkinson, and
José M Peregrín-Alvarez, and
Catherine Poole, and
Qinghu Ren, and
Lori Saunders, and
Ann E Sluder, and
Katherine Smith, and
Mario Stanke, and
Thomas R Unnasch, and
Jenna Ware, and
Aguan D Wei, and
Gary Weil, and
Deryck J Williams, and
Yinhua Zhang, and
Steven A Williams, and
Claire Fraser-Liggett, and
Barton Slatko, and
Mark L Blaxter, and
Alan L Scott
December 1999,
Magnetic resonance imaging,
