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Two dimensional NMR spectra of porcine brain natriuretic peptide have been recorded at 400 MHz. Peak assignments have been made and the combined information from chemical shifts, coupling constants, temperature coefficients, exchange studies and nuclear Overhauser effects has been used to determine the conformation of pBNP in aqueous media. Overall the peptide appears to be conformationally averaged with the possibility of some restricted flexibility in localized regions. The conformation of porcine brain natriuretic peptide in water is compared to previous studies in d6-DMSO and to studies of atrial natriuretic peptide and some closely related analogues in H2O and d6-DMSO.
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
April 1983,
Biochemistry,
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
July 1994,
Journal of molecular biology,
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
March 1976,
Biochemistry,
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
October 1990,
European journal of biochemistry,
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
January 1997,
Methods in enzymology,
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
May 1986,
Science (New York, N.Y.),
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
February 2005,
Magnetic resonance imaging,
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
May 1976,
Proceedings of the National Academy of Sciences of the United States of America,
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
November 1994,
The Journal of dairy research,
K J Nielsen, and
P R Barron, and
D J Craik, and
P F Lambert, and
J D Wade
March 2005,
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology,
