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Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. 2007
Kamil Paruch, and
Michael P Dwyer, and
Carmen Alvarez, and
Courtney Brown, and
Tin-Yau Chan, and
Ronald J Doll, and
Kerry Keertikar, and
Chad Knutson, and
Brian McKittrick, and
Jocelyn Rivera, and
Randall Rossman, and
Greg Tucker, and
Thierry O Fischmann, and
Alan Hruza, and
Vincent Madison, and
Amin A Nomeir, and
Yaolin Wang, and
Emma Lees, and
David Parry, and
Nicole Sgambellone, and
Wolfgang Seghezzi, and
Lesley Schultz, and
Fran Shanahan, and
Derek Wiswell, and
Xiaoying Xu, and
Quiao Zhou, and
Ray A James, and
Vidyadhar M Paradkar, and
Haengsoon Park, and
Laura R Rokosz, and
Tara M Stauffer, and
Timothy J Guzi
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. kamil.paruch@spcorp.com
Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.
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