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[The effect of non-steroidal anti-inflammatory drugs on upper gastrointestinal disorders in orthopaedic patients]. 2007

Yuji Uchio, and Ryuji Mori, and Junji Iwasa, and Hiroyuki Kakimaru, and Soichiro Yamamoto, and Hidetoshi Yamaguchi, and Wataru Miyamoto
Department of Orthopaedic Surgery, Shimane University School of Medicine.

We investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on upper gastrointestinal(GI) disorders in orthopaedic patients. Among a total of 1,923 patients (946 men and 977 women, mean age: 53 years) who received NSAIDs, 486 patients (25%) experienced some adverse reactions including mild GI symptoms, 364 patients (19%) had gastric mucosal lesion, and 37 patients (2%) had gastric ulcer. The number of patients with upper GI disorders was significantly higher in patients aged 50 years or older, than those under 50 years. Irrespective of the kinds of NSAIDs applied, our results suggest an increased risk of adverse effect causing upper GI disorders in orthopaedic patients who are administered NSAIDs for a long-term.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007592 Joint Diseases Diseases involving the JOINTS. Arthropathies,Arthropathy,Joint Disease
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010437 Peptic Ulcer Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS). Gastroduodenal Ulcer,Marginal Ulcer,Gastroduodenal Ulcers,Marginal Ulcers,Peptic Ulcers,Ulcer, Gastroduodenal,Ulcer, Marginal,Ulcer, Peptic,Ulcers, Gastroduodenal,Ulcers, Marginal,Ulcers, Peptic
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

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