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We have shown that during the developing phase of adjuvant disease (AD) in rats the expression of MHC class II (Ia) antigens on blood monocytes (BM) was enhanced. The results of a study in established AD are reported now. Four agents were tested: indomethacin and diclofenac-sodium (1 mg/kg/day); levamisole and prinomide (10 mg/kg/day), administered orally from day 18-31 after induction of AD. We assessed the following BM parameters: Ia expression, interleukin-1 (sIL-1) production, and membrane bound IL-1 (mIL-1). In AD Ia expression was enhanced, no changes occurred in mIL-1 or sIL-1. Indomethacin treatment reduced sIL-1 production, levamisole Ia expression and mIL-1 activity, prinomide all three parameters measured and diclofenac, though clinically effective, none.
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
November 1982,
Journal of immunology (Baltimore, Md. : 1950),
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
April 1990,
FEBS letters,
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
April 1987,
Immunopharmacology,
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
February 1994,
Lymphokine and cytokine research,
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
June 1986,
Life sciences,
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
May 1992,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
September 1993,
Masui. The Japanese journal of anesthesiology,
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
June 1985,
Journal of immunology (Baltimore, Md. : 1950),
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
October 1984,
Journal of immunology (Baltimore, Md. : 1950),
E J Schenkelaars, and
H N Singh, and
R L Goldberg, and
J R Doughty, and
J Peppard, and
G DiPasquale, and
F Quagliata
July 1999,
Journal of periodontology,
