BIOMAT Database Logo BIOMAT Database Logo

Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease. 2008

J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. seo-ji-a@hanmail.net

OBJECTIVE Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin-resistant states. We investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults. METHODS One hundred and fifty-nine nondiabetic, non-alcoholic subjects (95 males and 64 females) participated in this study. Division of subjects into a NAFLD group (n = 73; 45 males and 28 females) or a normal group (n = 86; 50 males and 36 females) was based on the presence of fatty liver disease determined by sonography. RESULTS Serum RBP4 levels in the NAFLD group were significantly higher than those in the normal group (62.8 +/- 16.0 mg/l vs. 51.7 +/- 14.6 mg/l, P < 0.0001). Multiple logistic regression analysis revealed that the RBP4 level was an independent factor associated with NAFLD (P = 0.0042). In addition, serum RBP4 levels were positively correlated with serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (GGT) levels. The significant association between serum RBP4 and GGT levels remained even after adjusting for age, gender, body mass index, the homeostasis model of assessment (HOMA) value and the presence of NAFLD (r = 0.3097, P = 0.0002). CONCLUSIONS Serum RBP4 levels are significantly associated with NAFLD and liver enzymes.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005234 Fatty Liver Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS. Liver Steatosis,Steatohepatitis,Steatosis of Liver,Visceral Steatosis,Liver Steatoses,Liver, Fatty,Steatohepatitides,Steatoses, Liver,Steatoses, Visceral,Steatosis, Liver,Steatosis, Visceral,Visceral Steatoses
D005260 Female Females
D005723 gamma-Glutamyltransferase An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid. GGTP,Glutamyl Transpeptidase,gammaglutamyltransferase,gamma-Glutamyl Transpeptidase,Transpeptidase, Glutamyl,Transpeptidase, gamma-Glutamyl,gamma Glutamyl Transpeptidase,gamma Glutamyltransferase
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000410 Alanine Transaminase An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2. Alanine Aminotransferase,Glutamic-Pyruvic Transaminase,SGPT,Alanine-2-Oxoglutarate Aminotransferase,Glutamic-Alanine Transaminase,Alanine 2 Oxoglutarate Aminotransferase,Aminotransferase, Alanine,Aminotransferase, Alanine-2-Oxoglutarate,Glutamic Alanine Transaminase,Glutamic Pyruvic Transaminase,Transaminase, Alanine,Transaminase, Glutamic-Alanine,Transaminase, Glutamic-Pyruvic
D001219 Aspartate Aminotransferases Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1. Aspartate Aminotransferase,Aspartate Transaminase,Glutamic-Oxaloacetic Transaminase,SGOT,Aspartate Apoaminotransferase,Glutamate-Aspartate Transaminase,L-Aspartate-2-Oxoglutarate Aminotransferase,Serum Glutamic-Oxaloacetic Transaminase,Aminotransferase, Aspartate,Aminotransferase, L-Aspartate-2-Oxoglutarate,Aminotransferases, Aspartate,Apoaminotransferase, Aspartate,Glutamate Aspartate Transaminase,Glutamic Oxaloacetic Transaminase,Glutamic-Oxaloacetic Transaminase, Serum,L Aspartate 2 Oxoglutarate Aminotransferase,Serum Glutamic Oxaloacetic Transaminase,Transaminase, Aspartate,Transaminase, Glutamate-Aspartate,Transaminase, Glutamic-Oxaloacetic,Transaminase, Serum Glutamic-Oxaloacetic
D014463 Ultrasonography The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz. Echography,Echotomography,Echotomography, Computer,Sonography, Medical,Tomography, Ultrasonic,Ultrasonic Diagnosis,Ultrasonic Imaging,Ultrasonographic Imaging,Computer Echotomography,Diagnosis, Ultrasonic,Diagnostic Ultrasound,Ultrasonic Tomography,Ultrasound Imaging,Diagnoses, Ultrasonic,Diagnostic Ultrasounds,Imaging, Ultrasonic,Imaging, Ultrasonographic,Imaging, Ultrasound,Imagings, Ultrasonographic,Imagings, Ultrasound,Medical Sonography,Ultrasonic Diagnoses,Ultrasonographic Imagings,Ultrasound, Diagnostic,Ultrasounds, Diagnostic

Related Publications

J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Circulating and liver tissue levels of retinol-binding protein-4 in non-alcoholic fatty liver disease.
October 2009, Hepatology research : the official journal of the Japan Society of Hepatology,
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease.
January 2009, Journal of clinical gastroenterology,
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Retinol Binding Protein-4 Levels and Non-alcoholic Fatty Liver Disease: A community-based cross-sectional study.
March 2017, Scientific reports,
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Elevated endotoxin levels in non-alcoholic fatty liver disease.
March 2010, Journal of inflammation (London, England),
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Elevated serum retinol-binding protein 4 levels are correlated with blood pressure in prehypertensive Chinese.
October 2017, Journal of human hypertension,
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Non-alcoholic fatty liver disease in overweight children and its relationship with retinol serum levels.
January 2008, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Retinol-binding protein-4 and nonalcoholic fatty liver disease.
May 2022, Chinese medical journal,
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Circulating retinol-binding protein 4 is associated with the development and regression of non-alcoholic fatty liver disease.
April 2020, Diabetes & metabolism,
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Regulation of retinol-binding protein 4 and retinol metabolism in fatty liver disease.
November 2016, Hepatology (Baltimore, Md.),
J A Seo, and N H Kim, and S Y Park, and H Y Kim, and O H Ryu, and K W Lee, and J Lee, and D L Kim, and K M Choi, and S H Baik, and D S Choi, and S G Kim
Serum adipocyte fatty acid-binding protein levels: An indicator of non-alcoholic fatty liver disease in Chinese individuals.
March 2019, Liver international : official journal of the International Association for the Study of the Liver,
Copied contents to your clipboard!