-transparent.png){kind=logo}
1. Oral administration of ethanol (3 ml) of 95% in 12 ml total volume over a two day period) significantly decrease plasma glucose and insulin levels and the activities of two key gluconeogenic enzymes, pyruvate carboxylase (pyruvate: CO2 ligase (ADP), EC 6.4.1.1) and fructose diphosphatase, (D-Fru-1,6-P2 1-phosphohydrolase, EC 3.1.3.11), and one glycolytic enzyme, fructose-1,6-P2 aldolase (Fru-1,6-P2 D-glyceraldehyde-3-P lyase, EC 4.1.2.13). In each instance, the administration of 2400 mug daily of oral folate in conjuction with the ethanol prevented these alterations in carbohydrate metabolism. 2. Intravenous injection of ethanol produced a rapid decrease (within 10--15 min) in the activities of hepatic phosphofructokinase, (ATP:D-fructose-6-phosphate 6-phosphotransferase, EC 2.7.1.11), pyruvate kinase, (ATP:pyruvate phosphotransferase, EC 2.7.1.40), fructose diphosphatase and fructose-1,6-P2 aldolase. 3. Intravenous ethanol significantly increased hepatic cyclic AMP concentration approximately 60% within 10 min, while oral ethanol did not alter hepatic cyclic AMP concentrations. 4. These data confirm the known antagonism ethanol and folate and suggest that oral folate might offer a protective effect against hypoglycemia in rats receiving ethanol.
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
August 2001,
Pharmacological research,
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
April 1977,
The Biochemical journal,
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
May 1978,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
July 1980,
Gastroenterology,
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
March 1985,
Pharmacological research communications,
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
May 1975,
Clinical pharmacology and therapeutics,
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
February 1984,
Gastroenterology,
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
January 1985,
Alcohol (Fayetteville, N.Y.),
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
June 1994,
Revista espanola de fisiologia,
F B Stifel, and
H L Greene, and
E G Lufkin, and
M R Wrensch, and
L Hagler, and
R H Herman
May 1988,
Digestive diseases and sciences,
