Phospholipid dependence of phospholipase C in rat liver plasma membranes. 1991

A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
Central Laboratory of Biophysics, Bulgarian Academy of Sciences, Sofia.

Investigations have been carried out on the lipid dependence of membrane-bound phosphatidylinositol-specific phospholipase C in rat liver plasma membranes. For this purpose the phospholipid composition of rat liver plasma membranes has been modified in two different ways. The first method included enrichment of plasma membranes with different phospholipids in the presence of lipid transfer proteins, and the second a partial delipidation by means of exogenous phospholipases A2 and C and selective enrichment with different phospholipids. The results indicated that almost all used phospholipids induced activation of phosphatidylinositol-specific phospholipase C except sphingomyelin. Phosphatidylethanolamine and egg yolk phosphatidylcholine were observed to be most effective in phospholipase C activation.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008563 Membrane Lipids Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation. Cell Membrane Lipid,Cell Membrane Lipids,Membrane Lipid,Lipid, Cell Membrane,Lipid, Membrane,Lipids, Cell Membrane,Lipids, Membrane,Membrane Lipid, Cell,Membrane Lipids, Cell
D010716 Phosphatidylinositols Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids. Inositide Phospholipid,Inositol Phosphoglyceride,Inositol Phosphoglycerides,Inositol Phospholipid,Phosphoinositide,Phosphoinositides,PtdIns,Inositide Phospholipids,Inositol Phospholipids,Phosphatidyl Inositol,Phosphatidylinositol,Inositol, Phosphatidyl,Phosphoglyceride, Inositol,Phosphoglycerides, Inositol,Phospholipid, Inositide,Phospholipid, Inositol,Phospholipids, Inositide,Phospholipids, Inositol
D010738 Type C Phospholipases A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS. Lecithinase C,Phospholipase C,Phospholipases, Type C,Phospholipases C
D010741 Phospholipases A Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002352 Carrier Proteins Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
January 1986, Biochimie,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
January 1986, The International journal of biochemistry,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
December 1987, The Biochemical journal,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
March 1973, Biochimica et biophysica acta,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
April 1994, Neurochemical research,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
December 1981, Agents and actions,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
February 1971, Biochimica et biophysica acta,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
August 1995, Biochimica et biophysica acta,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
December 1983, The Biochemical journal,
A B Momchilova-Pankova, and T T Markovska, and S E Koshlukova, and K S Koumanov
March 1986, FEBS letters,
Copied contents to your clipboard!