Effects of central epinephrine synthesis inhibition on stress-induced prolactin secretion in male rats. 1991

K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
Departamento de Ciências da Saúde, Universidade Federal de São Carlos, SP, Brasil.

1. The present study was designed to examine the role of central epinephrine pathways in the control of stress-induced prolactin secretion in male adult Wistar rats. 2. Intracerebroventricular administration of two epinephrine synthesis inhibitors, SKF 64139 (5 and 10 micrograms/rat) and LY 134046 (10 and 20 micrograms/rat), 6 h before the onset of immobilization stress blocked prolactin secretion in a dose-dependent manner. Prolactin values before stress were about 4.0 ng/ml and increased to almost 50 ng/ml in the control group. SKF 64139 injection in the higher dose (10 micrograms/rat) induced a complete blockade of the stress-induced prolactin release, whereas partial blockade was observed after the higher dose (20 micrograms/rat) of LY 134046. 3. Salbutamol pretreatment (10 micrograms/rat) completely restored stress-induced prolactin secretion in animals receiving a central injection of both epinephrine synthesis inhibitors under the same conditions as described above. 4. It is suggested that epinephrine pathways in the brain play an important role in the control of prolactin release occurring during immobilization stress.

UI MeSH Term Description Entries
D007276 Injections, Intraventricular Injections into the cerebral ventricles. Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D007546 Isoquinolines A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
D008297 Male Males
D008996 Monoamine Oxidase Inhibitors A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) MAO Inhibitor,MAO Inhibitors,Reversible Inhibitors of Monoamine Oxidase,Monoamine Oxidase Inhibitor,RIMA (Reversible Inhibitor of Monoamine Oxidase A),Reversible Inhibitor of Monoamine Oxidase,Inhibitor, MAO,Inhibitor, Monoamine Oxidase,Inhibitors, MAO,Inhibitors, Monoamine Oxidase
D011388 Prolactin A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate. Lactogenic Hormone, Pituitary,Mammotropic Hormone, Pituitary,Mammotropin,PRL (Prolactin),Hormone, Pituitary Lactogenic,Hormone, Pituitary Mammotropic,Pituitary Lactogenic Hormone,Pituitary Mammotropic Hormone
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D004837 Epinephrine The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. Adrenaline,4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol,Adrenaline Acid Tartrate,Adrenaline Bitartrate,Adrenaline Hydrochloride,Epifrin,Epinephrine Acetate,Epinephrine Bitartrate,Epinephrine Hydrochloride,Epinephrine Hydrogen Tartrate,Epitrate,Lyophrin,Medihaler-Epi,Acetate, Epinephrine
D000420 Albuterol A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol. Salbutamol,2-t-Butylamino-1-(4-hydroxy-3-hydroxy-3-hydroxymethyl)phenylethanol,Albuterol Sulfate,Proventil,Sultanol,Ventolin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001552 Benzazepines Compounds with BENZENE fused to AZEPINES.

Related Publications

K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
February 1989, The Journal of endocrinology,
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
January 1989, Journal of pineal research,
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
December 1981, Masui. The Japanese journal of anesthesiology,
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
January 1988, Polish journal of pharmacology and pharmacy,
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
January 1978, Life sciences,
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
January 1990, Endocrine research,
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
May 1982, Life sciences,
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
May 1979, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
February 1999, Archives of toxicology,
K O Nonaka, and M Midlej, and C Cobas, and M J Ramalho, and J B Fregoneze, and A Machado, and J Antunes-Rodrigues, and E de-Castro-e-Silva
February 1996, British journal of pharmacology,
Copied contents to your clipboard!