[Application of bone densitometry for detection of renal osteodystrophy in patients on maintenance haemodialysis]. 1994

V Tomanoski

In 48 pts on maintenance haemodialysis 6-140 months (mean 47.8 months) radiological, biochemical and densitometrical signs of renal osteodystrophy were evaluated. Bone densitometry, determination of Bone Mineral Content (BMC) by singl photon absorptiometry was performed. The following biochemical parameters included: serum calcium, serum phosphate, serum alkaline phosphatase and serum parathormon (RIA for C-terminal fragment). All pts were divided in three groups. The first group included 13 pts and had no radiological signs of renal osteodystrophy, the second included 24 pts and had radiological signs of osteitis fibrosa cystica, and the third included 11 pts who had radiological signs of osteomalacia. The mean values of duration on maintenance haemodialysis, biochemical parameters and BMC in these groups were compared. It was found that pts with radiological signs of osteitis fibrosa cystica had the highest levels of serum calcium, serum phosphate and serum parathormon, moderately elevated serum alkaline phosphatase and moderately decreased BMC. However, pts with radiological signs of osteomalacia had the longest duration of maintenance haemodialysis, the highest level of serum alkaline phosphatase and the lowest levels of serum calcium, serum phosphate, as the lowest BMC, but mild elevated serum parathormon. Our results showed good correlations between biochemical, radoilogical and densitometrical signs of second hyperparathyroidism, but these correlations are less valuable for osteomalacia. Bone densitometry in common with biochemical parameters and diagnostic radiology may contribute to better differentiation of the type of renal osteodystrophy.

UI MeSH Term Description Entries
D006962 Hyperparathyroidism, Secondary Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY. Secondary Hyperparathyroidism,Hyperparathyroidisms, Secondary,Secondary Hyperparathyroidisms
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010002 Osteitis Fibrosa Cystica A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM. Recklinghausen's Disease of Bone,Recklinghausen Disease of Bone,Recklinghausen Disease, Bone,Recklinghausens Disease, Bone
D010018 Osteomalacia Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis. Adult Rickets,Rickets, Adult
D012080 Chronic Kidney Disease-Mineral and Bone Disorder Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders. Renal Osteodystrophy,Renal Rickets,Rickets, Renal,CKD-MBD,Osteodystrophy, Renal,Chronic Kidney Disease Mineral and Bone Disorder,Osteodystrophies, Renal,Renal Osteodystrophies
D005260 Female Females
D006435 Renal Dialysis Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION. Dialysis, Extracorporeal,Dialysis, Renal,Extracorporeal Dialysis,Hemodialysis,Dialyses, Extracorporeal,Dialyses, Renal,Extracorporeal Dialyses,Hemodialyses,Renal Dialyses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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