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1. A rat isolated perfused kidney preparation was utilized to define clearly a renal site of action. The variables measured were perfusate pressure and flow, glomerular filtration rate, urine volume, sodium excretion and potassium excretion. 2. Dextromethorphan (3 nmol/L) and dextrorphan (10 nmol/L) reduced sodium excretion in kidneys from rats on either control or high K+ diet, in the absence of any other measured renal effects. Dextromethorphan (10 nmol/L) produced a decrease in glomerular filtration rate as well as a decrease in sodium excretion. Naloxone (1 mumol/L) inhibited the effect of dextromethorphan on sodium excretion but had no effect when administered alone. 3. The levorotatory opiates levorphanol and levomethorphan, the kappa agonist ketocyclazocine and a range of other opiates had no effect on sodium excretion. 4. The results suggest a renal action specific for dextrorotatory opiates. This renal action is consistent with earlier binding studies suggesting preferential recognition of dextrorotatory opiates.
A G Ellis, and
W R Adam
December 1975,
Life sciences,
A G Ellis, and
W R Adam
April 1980,
The Journal of pharmacology and experimental therapeutics,
A G Ellis, and
W R Adam
April 1978,
Clinical science and molecular medicine,
A G Ellis, and
W R Adam
September 2003,
The Journal of antimicrobial chemotherapy,
A G Ellis, and
W R Adam
September 2006,
Drug development and industrial pharmacy,
A G Ellis, and
W R Adam
November 1977,
Steroids,
A G Ellis, and
W R Adam
January 1981,
Drug metabolism and disposition: the biological fate of chemicals,
A G Ellis, and
W R Adam
August 1979,
The Journal of pharmacology and experimental therapeutics,
A G Ellis, and
W R Adam
January 1992,
Renal failure,
A G Ellis, and
W R Adam
June 1987,
Transplantation,
