Type 2 diabetes and impaired glucose tolerance among cardiac patients. 2007

Daniel A Enquobahrie, and Nino Dolidze, and Gulnara Chapidze, and Surab Vadachkoria, and Jason Soh, and Annette Fitzpatrick, and Michelle A Williams
Multidisciplinary International Research Training Program, University of Washington School of Public Health and Community Medicine, Seattle, Washington, 98101, USA. danenq@u.washington.edu

BACKGROUND Type 2 diabetes (T2D) and impaired glucose tolerance (IGT) are associated with increased cardiovascular diseases (CVD) morbidity and mortality. T2D and IGT prevalence and their relation to other risk factors were investigated among cardiac patients. RESULTS Patients (n = 250) visiting a secondary prevention clinic at the Emergency Cardiology Centre in Tibilisi, Republic of Georgia were enrolled in the study. Information on medical and surgical histories, CVD risk factors and current medical condition was obtained using interviews, medical record abstraction, physical examination and laboratory studies. Fasting blood glucose and 2-hour post load glucose concentrations were determined. Overall 40.8% (46% among men and 33% among women) of participants had T2D while 13% had IGT (13.4 among men and 12.9 among women). Of the T2D cases, more than half were previously undiagnosed. IGT and T2D were highly associated with dyslipidaemic profiles and elevated inflammatory marker concentrations in this population. Undiagnosed T2D cases shared similar CVD risk factors as previously diagnosed T2D cases including dyslipidaemia, other metabolic syndrome components and inflammation. CONCLUSIONS Both T2D (diagnosed and undiagnosed) and IGT are prevalent; and are associated with other important CVD risk factors among cardiac patients in the Republic of Georgia. Future studies assessing associations of T2D and IGT with CVD morbidity and mortality in this population, as well as studies that assess prevalence of T2D and IGT and their relation with CVD in the general population are needed.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010865 Pilot Projects Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work. Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D005260 Female Females
D005846 Georgia (Republic) A country in southwestern Asia, bordering the Black Sea, between Turkey and Russia. The capital is Tbilisi. Georgian S.S.R.,Georgia (Western Asia),Georgia SSR,Georgian SSR,Republic of Georgia
D005951 Glucose Tolerance Test A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg). Intravenous Glucose Tolerance,Intravenous Glucose Tolerance Test,OGTT,Oral Glucose Tolerance,Oral Glucose Tolerance Test,Glucose Tolerance Tests,Glucose Tolerance, Oral
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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