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The pathogenesis of experimental vaccinia virus infection in weanling mice after intracerebral inoculation was followed with virological, histological, and immunohistological methods. High-dose inoculation, virus spread from brain to thoracic and abdominal viscera probably by an undetected early viremia. Virus did rise to detectable levels in blood by day 5 and was found to be associated with the mononuclear cell fraction. By day 12, 30% of the animals had died and no further deaths occurred. Rise of neutralizing antibody correlated with disappearance of cell-free virus in blood, brain, and viscera. Virus was present in the brains of animals for 20 days after inoculation. This animal model may be useful to study mechanisms of persistent central nervous system virus disease relevant to man.
A H Ginsberg, and
K P Johnson
August 1982,
Lancet (London, England),
A H Ginsberg, and
K P Johnson
April 1951,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A H Ginsberg, and
K P Johnson
January 1953,
The Journal of infectious diseases,
A H Ginsberg, and
K P Johnson
January 2016,
Frontiers in microbiology,
A H Ginsberg, and
K P Johnson
September 1982,
Acta virologica,
A H Ginsberg, and
K P Johnson
November 2006,
Molecular biotechnology,
A H Ginsberg, and
K P Johnson
June 1943,
The Journal of experimental medicine,
A H Ginsberg, and
K P Johnson
January 1982,
Lancet (London, England),
A H Ginsberg, and
K P Johnson
March 1967,
Rivista di anatomia patologica e di oncologia,
A H Ginsberg, and
K P Johnson
January 1955,
The Journal of infectious diseases,
