-transparent.png){kind=logo}
Membrane lipid peroxidation by reactive oxygen species leading to increased capillary permeability is considered an important event in the pathogenesis of severe malaria. A significant decrease in plasma albumin and increases in cerebrospinal fluid (CSF) protein and malondialdehyde (MDA) were observed in 73 patients with cerebral malaria, compared to values in 23 control patients. The greatest effect was noticed in the most severely ill patients. The ratio of CSF protein to plasma albumin was increased in the patients compared to the controls, and in fatal cases of cerebral malaria compared to non-fatal cases. Brain necropsies showed oedema, fibrin deposits and mononuclear cell infiltration. It is proposed that cerebral oedema due to enhanced permeability of vascular endothelium induced by increased lipid peroxidation plays a crucial role in the causation of cerebral malaria.
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
January 1988,
Laboratornoe delo,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
January 1991,
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
July 2002,
Neurobiology of disease,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
October 2008,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
January 2000,
Vojnosanitetski pregled,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
December 1985,
Neurochemical research,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
December 1982,
No to shinkei = Brain and nerve,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
July 2023,
Redox biology,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
September 1985,
Tropical and geographical medicine,
B S Das, and
S Mohanty, and
S K Mishra, and
J K Patnaik, and
S K Satpathy, and
D Mohanty, and
T K Bose
January 1996,
Free radical biology & medicine,
