Biomaterial Database

Characterization of ST-4821 complex, a unique Neisseria meningitidis clone. 2008

Junping Peng, and Li Yang, and Fan Yang, and Jian Yang, and Yongliang Yan, and Huan Nie, and Xiaobing Zhang, and Zhaohui Xiong, and Yan Jiang, and Fan Cheng, and Xingye Xu, and Shuxia Chen, and Lilian Sun, and Weijun Li, and Yan Shen, and Zhujun Shao, and Xiaofeng Liang, and Jianguo Xu, and Qi Jin

State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Beijing 100052, China.

Ten outbreaks of a new serogroup C meningococcal disease emerged during 2003-2005 in China. The multilocus sequence typing results indicated that unique sequence type 4821 clone meningococci were responsible for these outbreaks. Herein, we determined the entire genomic DNA sequence of serogroup C isolate 053442, which belongs to ST-4821. Comparison of 053442 gene contents with other meningococcal genomes shows that they have similar characteristics, including thousands of repetitive elements and simple sequence repeats, numerous phase-variable genes, and similar virulence-related factors. However, many strain-specific regions were found in each genome. We also present the results of a genomic comparison of 28 ST-4821 complex isolates that were isolated from different serogroups using comparative genomic hybridization analysis. Genome comparison between the newly emerged hyperinvasive isolates belonging to different serogroups will further our understanding of their respective pathogenetic mechanisms.

UI	MeSH Term	Description	Entries
D008589	Meningococcal Infections	Infections with bacteria of the species NEISSERIA MENINGITIDIS.	Meningococcal Septicemia,Infections, Meningococcal,Meningococcal Disease,Infection, Meningococcal,Meningococcal Diseases,Meningococcal Infection,Septicemia, Meningococcal
D002681	China	A country spanning from central Asia to the Pacific Ocean.	Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D004196	Disease Outbreaks	Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.	Outbreaks,Infectious Disease Outbreaks,Disease Outbreak,Disease Outbreak, Infectious,Disease Outbreaks, Infectious,Infectious Disease Outbreak,Outbreak, Disease,Outbreak, Infectious Disease,Outbreaks, Disease,Outbreaks, Infectious Disease
D016680	Genome, Bacterial	The genetic complement of a BACTERIA as represented in its DNA.	Bacterial Genome,Bacterial Genomes,Genomes, Bacterial
D017422	Sequence Analysis, DNA	A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.	DNA Sequence Analysis,Sequence Determination, DNA,Analysis, DNA Sequence,DNA Sequence Determination,DNA Sequence Determinations,DNA Sequencing,Determination, DNA Sequence,Determinations, DNA Sequence,Sequence Determinations, DNA,Analyses, DNA Sequence,DNA Sequence Analyses,Sequence Analyses, DNA,Sequencing, DNA
D020071	Interspersed Repetitive Sequences	Copies of transposable elements interspersed throughout the genome, some of which are still active and often referred to as "jumping genes". There are two classes of interspersed repetitive elements. Class I elements (or RETROELEMENTS - such as retrotransposons, retroviruses, LONG INTERSPERSED NUCLEOTIDE ELEMENTS and SHORT INTERSPERSED NUCLEOTIDE ELEMENTS) transpose via reverse transcription of an RNA intermediate. Class II elements (or DNA TRANSPOSABLE ELEMENTS - such as transposons, Tn elements, insertion sequence elements and mobile gene cassettes of bacterial integrons) transpose directly from one site in the DNA to another.	Dispersed Repetitive Sequences,Genes, Jumping,Interspersed Repetitive Elements,Jumping Genes,Mobile Genetic Elements,Repetitive Sequences, Dispersed,Repetitive Sequences, Interspersed,Elements, Mobile Genetic,Genetic Elements, Mobile,Dispersed Repetitive Sequence,Element, Interspersed Repetitive,Element, Mobile Genetic,Elements, Interspersed Repetitive,Gene, Jumping,Genetic Element, Mobile,Interspersed Repetitive Element,Interspersed Repetitive Sequence,Jumping Gene,Mobile Genetic Element,Repetitive Element, Interspersed,Repetitive Elements, Interspersed,Repetitive Sequence, Dispersed,Repetitive Sequence, Interspersed,Sequence, Dispersed Repetitive,Sequence, Interspersed Repetitive,Sequences, Dispersed Repetitive,Sequences, Interspersed Repetitive
D038542	Neisseria meningitidis, Serogroup C	Strains of Neisseria meningitidis responsible for most sporadic cases in teenagers and almost all outbreaks of disease in this age group. These strains are less common in infants.	Meningococcus, Serogroup C,Meningococci, Serogroup C