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Twelve patients with preasthma (PA) and 27 bronchial asthma (BA) patients were examined for the effect of magnesium sulphate aerosol on bronchial sensitivity and reactivity to acetylcholine (ACC) and graded physical exercise (GPE) as well as on bronchial patency recorded by general plethysmography and pneumotachography. Inhalation of the drug was established to exert no bronchodilatory action but reduced, as compared with placebo, nonspecific hyperreactivity of the bronchial tree and blocked the ACC induced increment of histamine in the exhaled air condensate. The data obtained allow bronchial smooth muscles and mast cells to be regarded as targets for magnesium sulphate. The drug properties discovered may serve a prerequisite for its use in the combined treatment of BA patients and those with PA.
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
January 1996,
Klinicheskaia meditsina,
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
February 1987,
JAMA,
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
January 1996,
The Turkish journal of pediatrics,
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
January 1994,
The Journal of asthma : official journal of the Association for the Care of Asthma,
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
August 2016,
The American journal of emergency medicine,
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
February 1990,
Chest,
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
January 1997,
Terapevticheskii arkhiv,
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
October 1990,
Pneumologie (Stuttgart, Germany),
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
February 2000,
Indian journal of pediatrics,
G B Fedoseev, and
A V Emel'ianov, and
K K Malakauskas, and
V A Goncharova, and
T M Sinitsina, and
M D Didur, and
V L Emanuél', and
L V Krunchak
July 1992,
Revista clinica espanola,
