Psoralen plus ultraviolet A in the prophylactic treatment of benign summer light eruption. 1991

F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
Department of Dermatology, University of Reims, France.

We report the results of a French multicentre study to evaluate the efficiency of psoralen plus ultraviolet A (PUVA) therapy in the prophylactic treatment of benign summer light eruption (BSLE) and to establish the optimal protocol of radiation. Nine photobiology centres took part in this study; 83 patients (76 of them women) were evaluated. The radiation protocols were as follows: oral psoralen (8-methoxypsoralen; 0.6 mg/kg) was taken at each session; the starting dose of UVA radiation was determined according to skin type, with increments of 0.5 J/cm2 every 2 sessions. The subjects were randomized to receive 10-20 sessions 3 times per week. PUVA therapy was very effective: 68 patients (82%) reported total protection from BSLE. Four patients (5%) showed progress. Only 13% showed no improvement. The satisfactory results were not correlated with either the number of sessions or the J/cm2 of UVA. The intensity of tanning after the PUVA sessions did not appear to predict cure. Thirty-six percent of the patients had adverse reactions to treatment, including erythema, pruritus and triggering of BSLE. However, these effects only required the treatment to be stopped in 2% of the cases (for severe pruritus). The results in the various centres were similar.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010787 Photosensitivity Disorders Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy. Actinic Reticuloid Syndrome,Dermatitis, Actinic,Photodermatitis,Chronic Actinic Dermatitis,Photosensitization,Actinic Dermatitides,Actinic Dermatitides, Chronic,Actinic Dermatitis,Actinic Dermatitis, Chronic,Actinic Reticuloid Syndromes,Chronic Actinic Dermatitides,Dermatitides, Actinic,Dermatitides, Chronic Actinic,Dermatitis, Chronic Actinic,Disorder, Photosensitivity,Disorders, Photosensitivity,Photodermatitides,Photosensitivity Disorder,Reticuloid Syndrome, Actinic,Reticuloid Syndromes, Actinic,Syndrome, Actinic Reticuloid,Syndromes, Actinic Reticuloid
D011537 Pruritus An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief. Itching,Pruritis
D011701 PUVA Therapy Photochemotherapy using PSORALENS as the photosensitizing agent and ultraviolet light type A (UVA). Psoralen Ultraviolet A Therapy,Therapy, PUVA,PUVA Therapies,Therapies, PUVA
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012621 Seasons Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Seasonal Variation,Season,Seasonal Variations,Variation, Seasonal,Variations, Seasonal

Related Publications

F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
October 2010, Journal of the American Academy of Dermatology,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
February 2011, Photodermatology, photoimmunology & photomedicine,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
April 1986, Archives of dermatology,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
January 2002, Annales de dermatologie et de venereologie,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
October 1987, Journal of the American Academy of Dermatology,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
September 2013, The American journal of emergency medicine,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
December 2000, The British journal of dermatology,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
September 1979, Photochemistry and photobiology,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
October 2002, The British journal of dermatology,
F Leonard, and M Morel, and B Kalis, and P Amblard, and M Avenel-Audran, and J C Beani, and J M Bonnetblanc, and D Leroy, and M C Marguery, and J L Peyron
February 2005, Photodermatology, photoimmunology & photomedicine,
Copied contents to your clipboard!