-transparent.png){kind=logo}
Synthesis of 7-aryl/allyl-substituted androstene derivatives 3a through 3g has been carried out by Grignard reaction on 3 beta,17 beta-diacetoxyandrost-5-en-7-one (2) with aryl/allyl magnesium bromide. Isomeric mixture of products 3b and 3c/3e and 3f/3h was separated by column chromatography. Stereochemical assignment at C-7 has been made on the basis of 13C nuclear magnetic resonance studies and chemical considerations. Compounds 6a and 6b were synthesized by alkylation of compound 5 with beta-(N,N-diethylamino)ethyl chloride hydrochloride and 1-(2-chloroethyl)pyrrolidine hydrochloride, respectively. Compound 3g (isomeric mixture) prevented pregnancy in 60% of rats at 10 mg/kg daily dose administered orally on days 1 to 7 of pregnancy; however, its only isolable 7 beta-hydroxy isomer, 3h, was inactive at this dose.
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
October 2004,
Chemistry & biodiversity,
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
June 2011,
Molecules (Basel, Switzerland),
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
October 2017,
Steroids,
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
January 2007,
Steroids,
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
September 1966,
Journal of medicinal chemistry,
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
May 1996,
Journal of medicinal chemistry,
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
July 2010,
Archiv der Pharmazie,
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
July 1995,
Journal of medicinal chemistry,
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
October 1994,
Steroids,
A Grover, and
I Dwivedy, and
A K Singh, and
S Ray, and
M M Singh, and
V P Kamboj
January 2008,
Steroids,
