BIOMAT Database Logo BIOMAT Database Logo

Efficacy of doxorubicin coupled to lactosaminated albumin on rat hepatocellular carcinomas evaluated by ultrasound imaging. 2008

G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
Department of Experimental Pathology, University of Bologna, Bologna, Italy.

OBJECTIVE Doxorubicin was conjugated with lactosaminated human albumin, a hepatotropic drug carrier, in order to increase its efficacy in the treatment of hepatocellular carcinoma. In rats bearing hepatocellular carcinomas induced by diethylnitrosamine, lactosaminated human albumin coupled doxorubicin enhanced the drug concentrations in the tumours and lowered those in extrahepatic tissues. The aim of the present study was to investigate the effects of lactosaminated human albumin coupled doxorubicin on the growth of established rat hepatocellular carcinomas induced by diethylnitrosamine. METHODS Lactosaminated human albumin coupled doxorubicin and the free drug were i.v. administered to rats twice a week for 4 weeks at the single dose of 1 microg/g. Growth of individual tumours was followed through time by ultrasonography. RESULTS In the control animals injected with saline the mean area of the tracked tumours significantly increased during the whole period of treatment. In the group of rats treated with lactosaminated human albumin coupled doxorubicin the mean area of the followed hepatocellular carcinomas remained practically unchanged. The free drug inhibited tumour growth only in the first period of drug administration. Lactosaminated human albumin coupled doxorubicin also hindered the development of new neoplastic nodules, which was unaffected by the free drug. CONCLUSIONS The results support lactosaminated human albumin coupled doxorubicin as a promising agent for a systemic chemotherapy of hepatocellular carcinomas to treat noncurable patients.

UI MeSH Term Description Entries
D008114 Liver Neoplasms, Experimental Experimentally induced tumors of the LIVER. Hepatoma, Experimental,Hepatoma, Morris,Hepatoma, Novikoff,Experimental Hepatoma,Experimental Hepatomas,Experimental Liver Neoplasms,Hepatomas, Experimental,Neoplasms, Experimental Liver,Experimental Liver Neoplasm,Liver Neoplasm, Experimental,Morris Hepatoma,Novikoff Hepatoma
D008297 Male Males
D004052 Diethylnitrosamine A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. Nitrosodiethylamine,N-Nitrosodiethylamine,N Nitrosodiethylamine
D004317 Doxorubicin Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. Adriamycin,Adriablastin,Adriablastine,Adriblastin,Adriblastina,Adriblastine,Adrimedac,DOXO-cell,Doxolem,Doxorubicin Hexal,Doxorubicin Hydrochloride,Doxorubicin NC,Doxorubicina Ferrer Farm,Doxorubicina Funk,Doxorubicina Tedec,Doxorubicine Baxter,Doxotec,Farmiblastina,Myocet,Onkodox,Ribodoxo,Rubex,Urokit Doxo-cell,DOXO cell,Hydrochloride, Doxorubicin,Urokit Doxo cell
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000903 Antibiotics, Antineoplastic Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic
D012709 Serum Albumin A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules. Plasma Albumin,Albumin, Serum
D014463 Ultrasonography The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz. Echography,Echotomography,Echotomography, Computer,Sonography, Medical,Tomography, Ultrasonic,Ultrasonic Diagnosis,Ultrasonic Imaging,Ultrasonographic Imaging,Computer Echotomography,Diagnosis, Ultrasonic,Diagnostic Ultrasound,Ultrasonic Tomography,Ultrasound Imaging,Diagnoses, Ultrasonic,Diagnostic Ultrasounds,Imaging, Ultrasonic,Imaging, Ultrasonographic,Imaging, Ultrasound,Imagings, Ultrasonographic,Imagings, Ultrasound,Medical Sonography,Ultrasonic Diagnoses,Ultrasonographic Imagings,Ultrasound, Diagnostic,Ultrasounds, Diagnostic
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
The antitumor activity of a lactosaminated albumin conjugate of doxorubicin in a chemically induced hepatocellular carcinoma rat model compared to sorafenib.
February 2017, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
Hepatocyte targeting of adenine-9-beta-D-arabinofuranoside 5' -monophosphate (ara-AMP) coupled to lactosaminated albumin.
July 1981, FEBS letters,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
Gene transfer of endostatin enhances the efficacy of doxorubicin to suppress human hepatocellular carcinomas in mice.
September 2007, Cancer science,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
Erratum to: Imaging findings of fibrolamellar hepatocellular carcinomas on ultrasonography: A comparison with conventional hepatocellular carcinomas.
January 2021, Clinical hemorheology and microcirculation,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
Fusion imaging-guided radiofrequency ablation for hepatocellular carcinomas not visible on conventional ultrasound.
November 2013, AJR. American journal of roentgenology,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
9-beta-D-arabinofuranosyl-adenine 5' monophosphate coupled to lactosaminated albumin is not metabolized in mouse bloodstream.
January 1986, Pharmaceutica acta Helvetiae,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
Imaging findings of fibrolamellar hepatocellular carcinomas on ultrasonography: A comparison with conventional hepatocellular carcinomas.
January 2021, Clinical hemorheology and microcirculation,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
Conjugates of ara-AMP with lactosaminated albumin: a study on their immunogenicity in mouse and rat.
January 1987, Cancer drug delivery,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
[Imaging diagnosis of hepatocellular carcinomas].
January 1989, Gan to kagaku ryoho. Cancer & chemotherapy,
G Di Stefano, and L Fiume, and M Baglioni, and L Bolondi, and P Chieco, and F Kratz, and M Pariali, and G Rubini
Albumin-Albumin/Lactosylated Core-Shell Nanoparticles: Therapy to Treat Hepatocellular Carcinoma for Controlled Delivery of Doxorubicin.
November 2020, Molecules (Basel, Switzerland),
Copied contents to your clipboard!