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Stereoselective synthesis of 1'-functionalized-4'-thionucleosides. 2007

Lak Shin Jeong, and Prashantha Gunaga, and Hea Ok Kim, and Dilip K Tosh, and Hyuk Woo Lee, and Seung Ah Choe, and Hyung Ryong Moon, and Zhan-Guo Gao, and Kenneth A Jacobson, and Moon Woo Chun
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr

Stereoselective functionalization of the 1'-position of 4'-thionucleosides was achieved using a stereoselective S(N)2 reaction controlled by 5-membered ring coordination.

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006860 Hydrogen Bonding A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds. Hydrogen Bonds,Bond, Hydrogen,Hydrogen Bond
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer
D013872 Thionucleosides Nucleosides in which the base moiety is substituted with one or more sulfur atoms.
D015195 Drug Design The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include PHARMACOKINETICS, dosage analysis, or drug administration analysis. Computer-Aided Drug Design,Computerized Drug Design,Drug Modeling,Pharmaceutical Design,Computer Aided Drug Design,Computer-Aided Drug Designs,Computerized Drug Designs,Design, Pharmaceutical,Drug Design, Computer-Aided,Drug Design, Computerized,Drug Designs,Drug Modelings,Pharmaceutical Designs
D058918 Adenosine A3 Receptor Antagonists Compounds that selectively bind to and block the activation of ADENOSINE A3 RECEPTORS.

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