[The effects of lowering of blood pressure on pain sensitivity in spontaneously hypertensive rats]. 1991

S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.

It has been reported that elevation of blood pressure produces a reduction in pain sensitivity. This study was designed to clarify the correlation in spontaneously hypertensive rats (SHR) between fall in blood pressure and pain sensitivity. In seven-weeks-old male SHR, the angiotensin converting inhibitor delapril (10 mg/kg/day) or calcium antagonist nifedipine (3 mg/kg/day) was administered orally every day for 8 weeks. Systolic blood pressure (SBP) pretreatment was significantly higher in the SHR than in normotensive Wistar-Kyoto (WKY) rats and pain sensitivity measured with the hot plate method was significantly lower in the SHR than in the WKY rats. Administration of both drugs produced a significant suppression of elevation of SBP, and produced a significant elevation of pain sensitivity. Furthermore, at 8 weeks after drug administration, urinary norepinephrine (UNE) significantly decreased and plasma beta-endorphin (beta-end) significantly increased. A significant correlation was noted between pain sensitivity and SBP and also between pain sensitivity and UNE. Of these, pain sensitivity was the more closely correlated to degree of change in UNE than to degree of change in SBP. It appears that elevation of pain sensitivity is due to suppression of the sympathetic nervous system by antihypertensive drugs, but not to elevation of beta-end levels. These data suggest that a fall in blood pressure through administration of delapril or nifedipine reverses decrease in pain sensitivity in SHR and that decrease in sympathetic tone plays an important role in the restoration of levels of sensitivity to pain.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007189 Indans Aryl CYCLOPENTANES that are a reduced (protonated) form of INDENES. Indanones
D008297 Male Males
D009543 Nifedipine A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Adalat,BAY-a-1040,Bay-1040,Cordipin,Cordipine,Corinfar,Fenigidin,Korinfar,Nifangin,Nifedipine Monohydrochloride,Nifedipine-GTIS,Procardia,Procardia XL,Vascard,BAY a 1040,BAYa1040,Bay 1040,Bay1040,Monohydrochloride, Nifedipine,Nifedipine GTIS
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D010147 Pain Measurement Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies. Analgesia Tests,Analogue Pain Scale,Formalin Test,McGill Pain Questionnaire,Nociception Tests,Pain Assessment,Pain Intensity,Pain Severity,Tourniquet Pain Test,Visual Analogue Pain Scale,Analog Pain Scale,Assessment, Pain,McGill Pain Scale,Visual Analog Pain Scale,Analgesia Test,Analog Pain Scales,Analogue Pain Scales,Formalin Tests,Intensity, Pain,Measurement, Pain,Nociception Test,Pain Assessments,Pain Intensities,Pain Measurements,Pain Questionnaire, McGill,Pain Scale, Analog,Pain Scale, Analogue,Pain Scale, McGill,Pain Severities,Pain Test, Tourniquet,Questionnaire, McGill Pain,Scale, Analog Pain,Scale, Analogue Pain,Scale, McGill Pain,Severity, Pain,Test, Analgesia,Test, Formalin,Test, Nociception,Test, Tourniquet Pain,Tests, Nociception,Tourniquet Pain Tests
D011918 Rats, Inbred SHR A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. Rats, Spontaneously Hypertensive,Rats, SHR,Inbred SHR Rat,Inbred SHR Rats,Rat, Inbred SHR,Rat, SHR,Rat, Spontaneously Hypertensive,SHR Rat,SHR Rat, Inbred,SHR Rats,SHR Rats, Inbred,Spontaneously Hypertensive Rat,Spontaneously Hypertensive Rats
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012684 Sensory Thresholds The minimum amount of stimulus energy necessary to elicit a sensory response. Sensory Threshold,Threshold, Sensory,Thresholds, Sensory

Related Publications

S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
January 2013, Pharmacology,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
January 1987, Nephron,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
January 1975, Pharmacology,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
January 1990, Methods and findings in experimental and clinical pharmacology,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
September 1979, Japanese heart journal,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
September 2017, European journal of nutrition,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
July 2020, Journal of food biochemistry,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
March 2009, Archives of pharmacal research,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
February 2018, European journal of nutrition,
S Ogawa, and K Kuroda, and T Kikuchi, and H Shirai, and M Furusawa, and Y Akamine, and T Satoh, and M Fujii, and S Wakayama, and M Koizumi
February 2004, Fundamental & clinical pharmacology,
Copied contents to your clipboard!