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Three groups of swine (6/group) were used to assess alterations in regional brain blood flow induced by T-2 toxin. One group served as vehicle (70% ethanol) control, and groups were dosed intravascularly with T-2 toxin at 0.6 or 2.4 mg/kg body weight. Cerebral, cerebellar, and brain stem blood flows were evaluated at 0 h (predosing) and at 90-min intervals for 6 h postdosing. Fifteen-micron diameter radionuclide labeled microspheres were used to determine blood flow. Hemodynamic variables were determined at the same time points. The infusion of T-2 toxin resulted in dose-dependent reductions in both cardiac index and mean arterial pressure, accompanied by significant increases in heart rate. In animals given the lower dose of T-2 toxin, significant reductions in blood flow were evident in the cerebrums and cerebellum but not in the brain stem. Reductions in blood flow to all regions of the brain were evident in those animals given 2.4 mg T-2 toxin/kg. Brain blood flow was less severely compromised than was cardiac output, suggesting intact local autoregulation.
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
April 1987,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
December 1994,
American journal of veterinary research,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
January 1985,
Journal of cardiovascular pharmacology,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
May 1986,
Toxicology and applied pharmacology,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
June 1990,
Journal of neuroscience research,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
July 1995,
Progress in neuro-psychopharmacology & biological psychiatry,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
July 1991,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
January 1979,
Journal of agricultural and food chemistry,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
June 1994,
International journal of radiation oncology, biology, physics,
G R Lundeen, and
R H Poppenga, and
V R Beasley, and
R K Manuel, and
W B Buck, and
W J Tranquilli
April 1985,
American journal of veterinary research,
