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Adult male Wistar rats were submitted to normobaric hyperoxygenation for 1 and 4 hours, then brain synaptosomes were isolated and uptake and release of the histamine precursor - histidine (His), histamine (HA) level and His metabolizing enzymes activities were measured. This uptake in hyperoxic synaptosomes was inhibited by about 20%. After 1-hour hyperoxia, a tendency towards an increase of the HA level, but a significant increase histidine decarboxylase (HD) and histamine methyltransferase (HMT) activities were observed. Four-hour hyperoxia caused a decrease of both the HA level and the activities of both enzymes, especially HMT. The changes were reversed in 1-hour posthyperoxic recovery, except for histidine uptake which remained inhibited.
J Waśkiewicz, and
E Wałajtys-Rode, and
U Rafałowska
March 1987,
Biochemical pharmacology,
J Waśkiewicz, and
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U Rafałowska
August 1977,
Journal of neurochemistry,
J Waśkiewicz, and
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November 1987,
Life sciences,
J Waśkiewicz, and
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January 1980,
Voprosy meditsinskoi khimii,
J Waśkiewicz, and
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January 1985,
Neuropatologia polska,
J Waśkiewicz, and
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June 1982,
Journal of neurochemistry,
J Waśkiewicz, and
E Wałajtys-Rode, and
U Rafałowska
January 1991,
Free radical biology & medicine,
J Waśkiewicz, and
E Wałajtys-Rode, and
U Rafałowska
November 1972,
Biochemical pharmacology,
J Waśkiewicz, and
E Wałajtys-Rode, and
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January 2008,
Critical care medicine,
J Waśkiewicz, and
E Wałajtys-Rode, and
U Rafałowska
January 2000,
Anaesthesiologie und Reanimation,
