Biomaterial Database

Pharmacokinetics of second generation antidepressants: bupropion. 1991

P J Goodnick

Department of Psychiatry, University of Miami, FL 33136.

Bupropion is a relatively dopamine-specific antidepressant approved for release by the Food and Drug Administration in 1989. Topics included in this review are pharmacokinetics as related to blood levels and clinical response, bupropion's use in the elderly and in the medically impaired, and drug interactions of note.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000928	Antidepressive Agents	Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.	Antidepressant,Antidepressant Drug,Antidepressant Medication,Antidepressants,Antidepressive Agent,Thymoanaleptic,Thymoanaleptics,Thymoleptic,Thymoleptics,Antidepressant Drugs,Agent, Antidepressive,Drug, Antidepressant,Medication, Antidepressant
D016642	Bupropion	A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.	(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone,Amfebutamone,Bupropion Hydrochloride,Bupropion Hydrochloride, (+-)-Isomer,Bupropion, (+-)-Isomer,Quomen,Wellbutrin,Zyban (Anti-Smoking),Zyban (Bupropion),Zyntabac