OBJECTIVE To obtain an update of the treatment of advanced prostate cancer. METHODS Review of all published literature on advanced prostate cancer was carried out through medline and index medicus search. METHODS Published data on advanced prostate cancer from June 2005 to June 2007 was included in the review. METHODS Abstracts of articles identified were assessed, read and analysed to determine relevance to the title under review. RESULTS After establishing relevance from the abstract, the entire paper was read, and significant points included in the review. CONCLUSIONS The mainstay of treatment of advanced prostate cancer remains hormone withdrawal. The introduction of docetaxel based chemotherapy has caused a paradigm shift.