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A glucagon-saline solution (0.1 ml, 10(7) mole/100 g body weight) was injected via the portal vein into nonfasted Wistar and carbohydrate-sensitive BHE rats. Levels of liver and epididymal fat pad cyclic-AMP were observed after 6 and 24 minutes. When compared to sham injected rats at 6 minutes, glucagon injected rats of both strains had twice the level of cyclie-AMP in liver and fat pad tissue. By 24 minutes, the cyclic-AMP levels of the Wistar rats had decreased to those observed in their sham injected counterparts, and the concentration of liver cyclic-AMP in both sham injected and glucagon injected BHE rats had decreased to levels significantly below those observed in the Wistar rats. This observation suggests that a lipolytic-lipogenic imbalance may reside in the livers of rats of the BHE strain.
L B Gardner, and
E B Spannhake, and
S Reisher
September 1978,
Metabolism: clinical and experimental,
L B Gardner, and
E B Spannhake, and
S Reisher
May 1960,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L B Gardner, and
E B Spannhake, and
S Reisher
June 1977,
Archives internationales de pharmacodynamie et de therapie,
L B Gardner, and
E B Spannhake, and
S Reisher
January 1972,
Atherosclerosis,
L B Gardner, and
E B Spannhake, and
S Reisher
June 1981,
Biochemical and biophysical research communications,
L B Gardner, and
E B Spannhake, and
S Reisher
February 1977,
Diabetes,
L B Gardner, and
E B Spannhake, and
S Reisher
December 1977,
Diabetologia,
L B Gardner, and
E B Spannhake, and
S Reisher
December 1986,
Microscopia electronica y biologia celular : organo oficial de las Sociedades Latinoamericana de Microscopia Electronica e Iberoamericana de Biologia Celular,
L B Gardner, and
E B Spannhake, and
S Reisher
August 1970,
Acta physiologica Scandinavica,
L B Gardner, and
E B Spannhake, and
S Reisher
October 1967,
Diabetes,
