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Aldose reductase and aldehyde reductases have been purified to homogeneity from human kidney and have molecular weights of 32,000 and 40,000 and isoelectric pH 5.8 and 5.3, respectively. Aldose reductase, beside catalyzing the reduction of various aldehydes, reduces aldo-sugars, whereas aldehyde reductase, does not reduce aldo-sugars. Aldose reductase activity is expressed with either NADH or NADPH as cofactor, whereas aldehyde reductase utilizes only NADPH. Both enzymes are inhibited to varying degrees by aldose reductase inhibitors. Antibodies against bovine lens aldose reductase precipitated aldose reductase but not aldehyde reductase. The sequence of addition of the substrates to aldehyde reductase is ordered and to aldose reductase is random, whereas for both the enzymes the release of product is ordered with NADP released last.
N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
January 1991,
The International journal of biochemistry,
N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
May 1985,
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N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
June 1990,
Chemical & pharmaceutical bulletin,
N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
June 1989,
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N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
January 1994,
Enzyme & protein,
N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
January 1991,
Advances in experimental medicine and biology,
N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
February 1990,
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N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
October 1982,
European journal of biochemistry,
N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
April 1984,
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N H Ansari, and
A Bhatnagar, and
S Q Liu, and
S K Srivastava
January 1989,
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