-transparent.png){kind=logo}
To test the hypothesis that hyperfiltration in essential hypertension is linked to alterations in calcium metabolism, we studied the relationship between urinary calcium excretion and glomerular filtration rate (GFR, creatinine clearance) in 38 untreated essential hypertensives on a free diet. We also studied the influence of changes in calcium intake on GFR in 30 essential hypertensives (15 with well-defined hypercalciuria and 15 with normal urinary calcium excretion) and in 11 normotensive healthy subjects. In the patients on a free diet, urinary calcium excretion was directly and independently related to GFR (r = 0.56, P less than .001), while serum calcium showed an opposite trend (r = -0.27, P = .12). In patients on fixed calcium diets, GFR was significantly higher (P = .008) at low calcium intake (115 +/- 31 mL/min/1.73 m2) than at high calcium intake (98 +/- 22 mL/min/1.73 m2). Further analysis showed that the hyperfiltering effect of low calcium almost exclusively occurred in hypercalciuric patients and in hypertensive women. In hypercalciuric hypertensives there was a highly significant inverse correlation between GFR and serum calcium (r = -0.51, P = .004) and a similar correlation between GFR and plasma renin activity (r = -0.70, P = .003) in the high calcium phase of the study. Changes in calcium intake had no influence on GFR in normal subjects (Low Ca 103 +/- 22 mL/min/1.73 M2, High Ca 110 +/- 23 mL/min/1.73 m2). The data indicate that alterations in calcium metabolism interfere to an important extent with mechanism(s) regulating GFR in essential hypertension.
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
January 1996,
Contributions to nephrology,
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
January 1988,
Nephron,
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
January 1992,
Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma,
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
August 1983,
Clinical science (London, England : 1979),
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
July 1990,
Archives des maladies du coeur et des vaisseaux,
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
January 1996,
Contributions to nephrology,
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
May 1987,
European heart journal,
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
March 1988,
Southern medical journal,
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
January 1985,
Journal of cardiovascular pharmacology,
C Zoccali, and
F Mallamaci, and
M Postorino, and
F Cuzzola, and
D Leonardis, and
S Parlongo, and
F Salnitro
December 1990,
JAMA,
